TY - JOUR T1 - Initial Experience with routine 15O-water cardiac PET workflow JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 3001 LP - 3001 VL - 62 IS - supplement 1 AU - Susanne Hansen AU - Jeppe Madsen AU - Shakti Nicolai Johansen AU - Charlotte Jensen AU - Lone Winkler AU - Lars Gormsen AU - Lars Tolbod Y1 - 2021/05/01 UR - http://jnm.snmjournals.org/content/62/supplement_1/3001.abstract N2 - 3001Introduction: 15O-water is the ideal cardiac PET perfusion tracer due to its short half-life and extraction properties. However, the use of 15O-water has been limited due to the absence of commercial 15O-water generators. In December 2020, the first human exams using a novel bedside 15O-water generator designed for simple push button operation and high patient through-put (MT100, MedTrace Pharma, Denmark) were performed at Aarhus University Hospital, Denmark. In this study, we examine the potential for a 15O-water high-throughput workflow like the workflow known for 82Rb cardiac PET. Method: Ninety-three patients referred for routine cardiac perfusion PET were scanned using 15O-water PET (Dec 7, 2020 to Jan 5, 2021). The 15O-water was produced and infused using the MT100 bed-side water generator. The activity per scan was 400 MBq in 20 mL of saline infused at a speed of 2 mL/s. Each exam consisted of a low-dose CT followed by a 4 min rest dynamic PET scan and, finally, a 4 min stress dynamic PET scan. Pharmacological stress was induced using a 6 min infusion of adenosine (0.14 mg/kg/min) starting 2 min prior to the stress PET scan. The exam time (time from initiation of the low dose CT to the end of the stress PET scan) was monitored and compared to ninety 82Rb exams performed in the same institution (Dec 2, 2019 to Jan 6, 2020). Results: In this initial period, an average of 6 patients were scanned each day (a total of 16 scan days, 3-7 patients per day). The median exam time was 22 min (90% of the exams were below 25 min and 98% below 30 min). Exam time as low as 19 min was achieved in 6 exams. No exams were interrupted or cancelled due to technical issues. For 82Rb exams the median exam time was 19 min and 95% of exams were below 25 min. Conclusion: In the first 93 clinical exams performed, the median exam time for 15O-water cardiac PET was only 3 min longer compared to 82Rb. This suggests that 15O-water can replace 82Rb in a high patient throughput institution. ER -