TY - JOUR T1 - FDG PET/CT for prognostic stratification of patients with nodal peripheral T cell lymphoma. JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1687 LP - 1687 VL - 62 IS - supplement 1 AU - Woo Hee Choi AU - Eun Ji Han AU - Joo Hyun O AU - Seok-Goo Cho Y1 - 2021/05/01 UR - http://jnm.snmjournals.org/content/62/supplement_1/1687.abstract N2 - 1687Objectives: This study aimed to evaluate the prognostic significance of FDG PET/CT in patients with nodal peripheral T cell lymphoma (PTCL). Methods: We retrospectively reviewed 71 patients with histologically confirmed nodal PTCL who performed FDG PET/CT at baseline, after 3 cycles of first-line chemotherapy (interim), and after completion of chemotherapy (final). Response was assessed visually by Deauville 5-point scale (D5PS), and scores 1, 2, and 3 were considered PET-negative and scores 4 and 5 were considered PET-positive. The association between FDG PET response and survival was assessed using Cox regression analysis. Results: In total, FDG PET/CT images of 71 patients (40 male and 31 female; median age, 57 years, range, 18-77 years) were included. Of these patients, 13 (18.3%) had interim PET-positive result and 13 (18.3%) had final PET-positive result. The median overall (OS) and progression-free survival (PFS) were 16 and 40 months, respectively. Interim PET-positive result was a significant independent prognostic factor for PFS (Hazard ratio 2.551, p=0.018) in both univariate and multivariate analysis. Final PET-positive result was a significant independent prognostic factor of poor PFS (Hazard ratio 2.826, p=0.011) and OS (Hazard ratio 4.546, p=0.001). Conclusions: Interim and final PET/CT response based on D5PS were important prognostic parameters in patients with nodal PTCL. ER -