RT Journal Article
SR Electronic
T1 C-met receptor-targeted fluorescence-guided surgery in penile squamous cell carcinoma patients
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1219
OP 1219
VO 62
IS supplement 1
A1 Hielke-Martijn de Vries
A1 Matthias Van Oosterom
A1 Fijs Van Leeuwen
A1 Oscar Brouwer
A1 Tessa Buckle
YR 2021
UL http://jnm.snmjournals.org/content/62/supplement_1/1219.abstract
AB 1219Introduction: In penile squamous cell carcinoma (pSCC), primary surgery aims to obtain oncologically safe margins while minimising mutilation. Surgical guidance provided by receptor-specific tracers could potentially improve margin detection and reduce excision of healthy tissue. Here, we present the first results of a prospective feasibility study for real-time intraoperative visualisation of pSCC using a fluorescent c-MET receptor targeting tracer. Methods: Tracer performance was initially assessed ex vivo, via incubation of freshly excised pSCC in a solution containing EMI-137 (N=10). The in vivo potential of c-Met targeting and intraoperative tumor visualization was assessed after intravenous administration of EMI-137 in five pSCC patients scheduled for surgical resection. Fluorescence imaging results were related to standard pathological evaluation, including immunohistochemistry. Results: No tracer-related adverse events were encountered. EMI-137 enabled tumour visualisation in all patients. C-MET expression was seen in all patients and the highest expression levels were seen at the tumour borders. A visual correlation was observed between c-MET expression and fluorescence signal intensity. Conclusions: Our initial findings support the feasibility of fluorescence-guided surgical resection of c-MET receptor expressing pSCC tumours, thereby paving the way for further development of this surgical guidance approach.