TY - JOUR T1 - Clinical Value of PET/CT and PET/MRI for the Assessment of Rheumatic Diseases JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 2005 LP - 2005 VL - 62 IS - supplement 1 AU - Siavash Mehdizadeh Seraj AU - William Raynor AU - Thomas Werner AU - Abass Alavi AU - Mona-Elisabeth Revheim Y1 - 2021/05/01 UR - http://jnm.snmjournals.org/content/62/supplement_1/2005.abstract N2 - 2005Objectives: To describe the applications of PET/CT and PET/MRI in rheumatic diseases. Methods: Over the past decades, the use of PET for the assessment of musculoskeletal and rheumatologic diseases has increased. This can be attributable to the advancements in understanding the pathophysiology of such diseases in addition to fusing PET images with structural imaging modalities such as CT and MRI. FDG-PET has the ability to identify the inflammation early in the disease due to the increased glucose utilization in the cells in such conditions. NaF-PET is able to detect degenerative processes in the joints. Moreover, NaF-PET can be used to assess osteoporosis as well as extra-osseous early calcification such as atherosclerotic micro-calcification in the arteries, disorders more common in rheumatic patients. Therefore, PET-CT/MRI with FDG and NaF can be utilized to evaluate joint disease, bone health, and cardiovascular system in patients with rheumatologic diseases. Results: We are going to describe the utility of PET/CT-MRI in major rheumatic disorders such as rheumatoid arthritis, systemic lupus erythematosus, polymyalgia rheumatica spondyloarthropathies, and associated/secondary conditions such as atherosclerosis and osteoporosis. The main topics that are going to be discussed include 1) role of FDG-PET/CT-MRI in the assessment of joints 2) role of FDG-PET/CT-MRI in the assessment of extra-articular inflammation. 3) role of NaF-PET/CT-MRI in the assessment of joints. 4) role of NaF-PET/CT-MRI in the assessment of osteoporosis. 5) role of NaF-PET/CT-MRI in the assessment of atherosclerosis 6) PET quantification methods to evaluate rheumatic diseases. Conclusions: This educational exhibit will highlight the role of utilizing PET/CT and PET/MRI in the assessment of rheumatic diseases. We will discuss the advantages and limitations of these modalities in such conditions. ER -