TY - JOUR T1 - The alteration of FDG uptake in the right ventricular myocardium before and after lung transplantation in patients with chronic respiratory failure. JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1645 LP - 1645 VL - 62 IS - supplement 1 AU - Shigeki Nagamachi AU - Masanari Nonokuma AU - Yasuo Kuwabara AU - Takeshi Shiraishi AU - Kengo Yoshimitsu Y1 - 2021/05/01 UR - http://jnm.snmjournals.org/content/62/supplement_1/1645.abstract N2 - 1645Background: Right ventricular failure is one of serious complication due to chronic respiratory failure. Although the lung transplantation is curative surgical methods for chronic respiratory dysfunction, few studies have reported about the course of right ventricular functional images before and after lung transplantation. In the present study, we evaluated the alteration of right ventricular function by monitoring FDG uptake of right ventricular myocardium before and after lung transplantation. Methods: Twenty patients who were undergone lung transplantation for the curative therapy of chronic refractory pulmonary failure were analyzed retrospectively. All patients were done FDG-PETCT before and after lung transplantation within 2 years. In the quantitative analyzes by on FDG-PET CT, both SUVmax of both ventricular myocardium and the ratios of SUV max between right ventricle myocardium and left ventricle myocardium (R/L ratio) were obtained. The data of 15 normal controls data were compared with patient's data. Results: In the visual analysis, 6 of 20 patients showed increased right ventricular myocardial uptake. All these cases changed to be normal myocardial uptake after lung transplantation. In the semi-quantitative analysis, in the patients before the transplantation, the mean value of SUVmax in the right ventricle myocardium was 2.92±0.43 and the R/L ratio were 0.67±0.24. After lung transplantation, the mean value of SUVmax in the right ventricle myocardium was 2.04±1.27 and the R/L ratio was 0.53±0.14. They were significantly lower than those of pre-transplantation values. In the normal control, the value of SUVmax in the right ventricle myocardium was 1.96±0.75 and the value of R/L ratio was 0.52±0.28. Although both indexes of pre-transplantation patient’s values were significantly higher than those of normal controls values, there were no statistical significance between post-transplantation patient’s values and normal control values. Conclusions: In some cases with chronic respiratory failure, increased right ventricular myocardial FDG uptake was noted, which uptake decreased after lung transplantation. FDG-PET will be useful in monitoring the right ventricular overload in the chronic respiratory failure which can be relieved by pulmonary transplantation. Clinical implication: Myocardial FDG-PET/CT examinations before and after the pulmonary transplantation will be useful for diagnosing right ventricular overload and its therapeutic-effect by lung transplantation. ER -