RT Journal Article
SR Electronic
T1 F-18 FDG uptake predicts progression-free and overall survival in patients with nonmetastatic human papillomavirus-related oropharyngeal squamous cell carcinoma
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1089
OP 1089
VO 62
IS supplement 1
A1 Hojin Cho
A1 Soyoung Kim
A1 Kwanhyeong Jo
A1 Yong Hyu Jeong
A1 Won Jun Kang
YR 2021
UL http://jnm.snmjournals.org/content/62/supplement_1/1089.abstract
AB 1089Introduction: We evaluated prognostic roles of baseline F-18 FDG PET/CT in patients with nonmetastatic HPV-positive oropharyngeal cancer squamous cell carcinoma. Methods: We retrospectively reviewed patients who diagnosed with stage I, II and III HPV-positive oropharyngeal squamous cell carcinoma in Severance Hospital from 2010 to 2015, who performed baseline F-18 FDG PET/CT. Patient who had a history of other malignancy were excluded. Mean SUV of the normal liver, and maximum SUV, metabolic tumor volume (MTV), total lesion glycolysis (TLG), and coefficient of variation (CV) of the primary tumor were measured. SUV was normalized using mean liver SUV. Patients were treated with curative resection and/or chemoradiation. End points were progression-free survival (PFS) and overall survival (OS). Results: A total of 90 patients (male, 72; female, 18) were enrolled. Patients were followed up for 60.5 ± 21.2 (mean ± SD) months. During follow-up period, 15 patients were progressed, and 13 died. In univariate analysis, patients with higher overall stage (III vs I-II), tumor stage (T4 vs T1-T3), tumor to liver SUV ratio (TLR), MTV, TLG, and CV, and patient who received chemoradiation, as compared to who underwent surgery with/without chemoradiation, were associated with poorer PFS and OS. Multivariate analysis revealed that patients with advanced overall stage, and higher TLR or CV had poorer PFS and OS. Conclusion: We showed that TLR and CV of the primary tumor on baseline F-18 FDG PET/CT were associated with poorer PFS and OS in patients with nonmetastatic HPV-positive oropharyngeal squamous cell carcinoma. Further study is needed to address possible implications of F-18 FDG PET/CT in deciding treatment intensification or deintensification in these patients.