TY - JOUR T1 - The Latest Advances in Imaging Crosstalk Between the Immune System and Fibrosis in Cardiovascular Disease JF - Journal of Nuclear Medicine JO - J Nucl Med DO - 10.2967/jnumed.120.255539 SP - jnumed.120.255539 AU - Gyu Seong Heo AU - Lanlan Lou AU - Deborah Sultan AU - Yongjian Liu Y1 - 2021/04/01 UR - http://jnm.snmjournals.org/content/early/2021/04/16/jnumed.120.255539.abstract N2 - Inflammation and fibrosis are hallmarks of tissue repair process and organ failure progression in cardiovascular diseases. Paradigm-shifting research on diverse immune cell populations within the cardiovascular system have enabled discovery of new biomarkers fostering development of diagnostic and therapeutic agents at the molecular level to better manage cardiovascular diseases. To date, a variety of molecular imaging agents have been developed to visualize the biomarkers expressed on immune cells and fibroblasts within their crosstalk network, which drives the pathogenesis of fibrosis triggered by both innate and adaptive immunity. Herein, key biomarkers up-regulated in the immune-fibrosis axis are discussed. The promising molecular imaging agents to reveal this critical pathological process are summarized. ER -