RT Journal Article
SR Electronic
T1 Slow but evident recovery from neocortical dysfunction and cognitive impairment in a series of chronic COVID-19 patients
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP jnumed.121.262128
DO 10.2967/jnumed.121.262128
A1 Ganna Blazhenets
A1 Nils Schröter
A1 Tobias Bormann
A1 Johannes Thurow
A1 Dirk Wagner
A1 Lars Frings
A1 Cornelius Weiller
A1 Philipp T Meyer
A1 Andrea Dressing
A1 Jonas A Hosp
YR 2021
UL http://jnm.snmjournals.org/content/early/2021/03/31/jnumed.121.262128.abstract
AB Cognitive impairment is a frequent complaint in coronavirus disease-19 (COVID-19) and can be related to cortical hypometabolism on 18F-FDG PET at the subacute stage. However, it is unclear if these changes are reversible. Methods: We prospectively assessed Montreal Cognitive Assessment (MoCA) and 18F-FDG PET scans in 8 COVID-19 patients at the subacute (as no longer infectious) and chronic stages (approximately six months after symptom onset). The expression of the previously established COVID-19-related covariance pattern was analyzed at both stages to examine the time course of post-COVID-19 cognitive impairment. For further validation, we also conducted a conventional group analysis. Results: Follow-up 18F-FDG PET revealed a significant reduction of initial frontoparietal and, to a lesser extent, temporal glucose hypometabolism that was accompanied by a significant improvement in cognition. The expression of the previously established COVID-19-related pattern was significantly lower at follow-up and correlated inversely with MoCA performance. However, both 18F-FDG PET and cognitive assessment suggest a residual impairment. Conclusions: Although a significant recovery of regional neuronal function and cognition can be clearly stated, residuals are still measurable in some patients six months after the manifestation of COVID-19. Given the current pandemic situation and tremendous uncertainty concerning the long-term effects of COVID-19, the present study provides novel insights of highest medical and socioeconomic relevance.