Discussions with leaders: JNM editor-in-chief Johannes Czernin talks with Howard Soule, of the Prostate Cancer Foundation, about supporting and encouraging research in an environment of rapidly changing scientific knowledge and clinical practice.
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Leading in a time of pandemic: Johnese Spisso, president of UCLA Health and CEO of the UCLA Hospital System, discusses with JNM editor-in-chief Johannes Czernin challenges and strategies in managing health-care delivery during the COVID-19 outbreak.
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Bombesin imaging in cancer: Baratto and colleagues offer a state-of-the-art overview of the bombesin receptor family, with a focus on gastrin-releasing peptide receptors and on applications in prostate and breast cancers.
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Molecular imaging of bone metastases: Cook and Goh provide an educational review of the role of new molecular and hybrid methods, including SPECT/CT, PET/CT, and whole-body MR, for imaging bone metastases.
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Aromatase imaging in breast cancer: Biegon and colleagues validate and optimize PET imaging with 11C-vorozole for in vivo measurement of aromatase expression in individual breast cancer lesions in postmenopausal women.
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PET/CT radiomics in lung cancer SBRT: Dissaux and colleagues develop and evaluate a prognostic 18F-FDG PET/CT radiomic signature in early-stage non–small cell lung cancer patients treated with stereotactic body radiotherapy.
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18F-FDG PET/CT and hyperprogressive cancer: Castello and colleagues use 18F-FDG PET/CT to investigate the prevalence of hyperprogressive disease as a pattern of response during treatment of non–small cell lung cancer with immune checkpoint inhibitors.
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11C-Choline PET/CT in recurrent prostate cancer: Michaud and colleagues report on the performance of 11C-choline PET/CT in detecting biochemically recurrent prostate cancer in a large non-European cohort and describe patterns of recurrence.
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Integrated roadmap for fluorescence guidance: Meershoek and colleagues detail the role of positional data from SPECT/CT in providing a 3D preoperative imaging road map for fluorescence-guided surgery in prostate cancer.
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Co-clinical imaging: Savaikar and colleagues develop and optimize image metrics for 18F-FDG PET to assess response to combination docetaxel and carboplatin therapy in a co-clinical trial involving triple-negative breast cancer patient–derived xenografts.
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PARP-1–targeted Auger therapy: Lee and colleagues assess the cytotoxicity of chromatin-targeted Auger therapy in preclinical models of high-risk neuroblastoma and discuss the potential for use in micrometastatic disease.
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177Lu-PSMA-617 in prostate cancer: Violet and colleagues report longer-term outcomes in an expanded cohort from a trial of this prostate-specific membrane–targeting radioligand in men with metastatic castration-resistant prostate cancer.
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3-Year freedom from progression in BCR: Emmett and colleagues describe the predictive value of 68Ga-prostate-specific membrane antigen PET for 3-y freedom from progression in men with biochemical recurrence of prostate cancer undergoing salvage radiotherapy.
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68Ga-PSMA PET/CT and PTEN–loss PCa: Wang and colleagues explore the value of 68Ga-prostate-specific membrane antigen PET/CT for detection of phosphatase and tensin homolog–loss prostate cancer.
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18F-DCFPyL PET/CT in prostate cancer: Mena and colleagues investigate the lesion detection rate of this prostate-specific membrane antigen–targeted PET agent in patients with biochemically relapsed prostate cancer after primary local therapy.
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64Cu-DOTATATE in NETs: Delpassand and colleagues prospectively determine the lowest optimal dose of this tracer and evaluate its diagnostic performance and safety in a phase III study of patients with somatostatin receptor–expressing neuroendocrine tumors.
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68Ga-DOTA-JR11 in NETs: Zhu and colleagues compare PET/CT results with this somatostatin receptor subtype 2–specific antagonist with those from 68Ga-DOTATATE in patients with metastatic, well-differentiated neuroendocrine tumors.
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Glucose transport in neuroendocrine prostate cancer: Bakht and colleagues evaluate the association between neuroendocrine gene signature and 18F-FDG uptake–associated genes in prostate cancer, including glucose transporters and hexokinases.
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18F-PI-2620 tau PET in humans: Mueller and colleagues assess the ability of imaging with this PET tracer to detect tau pathology in patients with Alzheimer disease and report on associated safety and tolerability.
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18F-PI-2620 kinetics and quantification: Bullich and colleagues detail the biodistribution, dosimetry, quantitative methods, and test–retest variability of this next-generation tau PET tracer in the human brain.
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Brain nicotine uptake and E-cigarettes: Solingapuram Sai and colleagues use 11C-nicotine PET to describe brain nicotine uptake and kinetics after inhalation from electronic cigarettes and compare these with results from smoking combustible cigarettes.
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Accuracy of 2-FDG determinations: Barrio and colleagues look at potential limitations of assuming 2-FDG as a surrogate for glucose metabolic rate and potential reasons for variability in the lump constant.
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- © 2020 by the Society of Nuclear Medicine and Molecular Imaging.