Molecular imaging in immunotherapy: Ehlerding and colleagues outline current applications of noninvasive techniques for preclinical imaging of immunotherapy targets and suggest future pathways for molecular imaging in this developing field.
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New theranostic paradigm for DTC: Pattison and colleagues review the current role of molecular imaging in differentiated thyroid cancer and preview an article in this issue of JNM incorporating somatostatin receptor imaging in this setting.
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PET renal GFR: Blaufox assesses the promise and challenges of nuclear medicine techniques in renal function evaluation and previews an article in this issue of JNM using a PET agent to measure glomerular filtration rates.
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Reverse translation: Albin and Frey look at the potential of studies that “reverse” conventional scientific workflow by assessing clinical results in preclinical models and preview a related article in this issue of JNM focusing on biomarkers in Parkinson disease.
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PET/CT and response in DTC: Jentzen and colleagues analyze pretherapy and follow-up 124I PET/CT data on bone metastases from differentiated thyroid cancer patients to assess relationships between absorbed radiation dose with and response after initial radioiodine treatment.
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Pretargeted immuno-PET in MTC: Bodet-Milin and colleagues report on optimized molar doses and pretargeting intervals of an anticarcinoembryonic antigen bispecific antibody and 68Ga-labeled IMP288 for immuno-PET in relapsed medullary thyroid carcinoma.
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SSTR PET/CT in DTC: Binse and colleagues evaluate the impact of 68Ga-DOTATOC PET/CT in detecting recurrence or metastases in patients with differentiated thyroid carcinoma and elevated serum thyroglobulin with negative radioiodine and 18F-FDG PET/CT results.
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Breast parenchymal uptake on PET/CT: Leithner and colleagues quantitatively assess breast parenchymal uptake on 18F-FDG PET/CT as an imaging biomarker and examine its correlation with background parenchymal enhancement, amount of fibroglandular tissue, and age.
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HER2+ PET in HER2− breast cancer: Ulaner and colleagues determine whether imaging with a human epidermal growth factor receptor 2–targeted PET tracer can detect HER2-positive metastases in patients with HER2-negative primary breast cancer.
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Simplified quantification of 18F-FE-PE2I: Sonni and colleagues identify the optimal acquisition time window for this new dopamine transporter PET radioligand and validate the specific binding ratio as a simplified quantification method in Parkinson disease.
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18F-AV-1451 tracer kinetics: Shcherbinin and colleagues report on kinetic modeling results for dynamic acquisition data with this PET tau tracer in cognitively normal individuals and individuals with mild cognitive impairment and Alzheimer disease.
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Parametric imaging of 18F-DPA-714: Golla and colleagues identify the best method for generating quantitative parametric images of binding for this PET radioligand for the 18-kDa translocator protein.
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Real-time microfluidic radioassay: Liu and colleagues describe a continuously infused microfluidic radioassay system for real-time in-culture measurement of cellular uptake, with initial tests on the influence of cellular glucose concentration on 18F-FDG uptake kinetics.
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PET in myelofibrosis: Derlin and colleagues assess the feasibility of 18F-FDG PET/CT for noninvasive monitoring of treatment response after allogeneic stem cell transplantation in patients with myelofibrosis.
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Radionuclide evaluation of brain death: Zuckier provides an educational overview of the evolution of scintigraphy in brain death, current clinical and imaging practice guidelines, limitations, and potential future expanded roles.
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211At-6 for PSMA-targeted α-therapy: Kiess and colleagues report on preclinical results with a urea-based, 211At-labeled small molecule–targeting prostate-specific membrane antigen in mice bearing prostate cancer micrometastases.
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Vascular-targeted radioimmunotherapy: Behling and colleagues investigate antibody targeting of the vascular endothelium of glioblastoma with cytotoxic short-range, high-energy α-particles in a clinically relevant transgenic glioblastoma mouse model.
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Dual-activity vascular inflammation imaging: Withana and colleagues report on activity-based probes targeting cysteine cathepsins that can be used in murine models of atherosclerosis to noninvasively image activated macrophage populations with both optical and PET/CT methods.
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Brain network activity and cell implantation: Peng and colleagues use PET to examine changes in brain network activity caused by striatal implantation of human levodopa-producing retinal pigment epithelial cells in parkinsonian macaques.
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18F-MK-6240 and NFTs: Hostetler and colleagues describe preclinical characterization of this PET tracer targeting the neurofibrillary tangles associated with Alzheimer disease.
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CD3 PET and immune therapy response: Larimer and colleagues examine the potential of 89Zr-labeled, T-cell–targeting PET as a predictive marker in a murine model of colon cancer immunotherapy.
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Imaging AT1R-specific binding: Hachem and colleagues assess the binding profile of 18F-FPyKYNE-losartan, a novel PET agent for imaging the angiotensin type 1 receptor.
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Specific activity in integrin PET: Notni and colleagues investigate the influence of specific activities of 68Ga-aquibeprin and 68Ga-avebetrin tracers for selective in vivo PET mapping of integrins α5β1 and αvβ3, respectively.
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18F-fluorodeoxysorbitol renal PET: Wakabayashi and colleagues test in rats the feasibility of renal PET imaging with this analog of sorbitol that is freely filtered at the renal glomerulus without reabsorption at the tubule.
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Cystine knot peptide photoacoustic imaging: Zhang and colleagues report on development and evaluation of a dye-labeled cystine knot peptide that selectively recognizes integrin αvβ6 with high affinity for photoacoustic and fluorescence imaging.
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CT prediction from MR images: Wu and colleagues present a patch-based method for CT prediction from MR images, generating attenuation maps for PET reconstruction requiring no image segmentation or registration.
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PVE correction in oncologic PET/CT: Cysouw and colleagues explore the effect of partial-volume correction combined with several volume-of-interest methods on the accuracy and precision of quantitative PET.
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Fluorescence camera navigation: KleinJan and colleagues evaluate the feasibility of a nuclear medicine–based navigation concept that allows intraoperative positioning of a fluorescence camera in the vicinity of preoperatively defined sentinel nodes containing indocyanine green–99mTc-nanocolloid.
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ASNC/SNMMI on PET MPI: Bateman and a collaborative team of experts from the American Society of Nuclear Cardiology and SNMMI release a joint position statement on clinical indications for PET myocardial perfusion imaging.
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- © 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.