Cardiovascular molecular imaging: Majmudar and Nahrendorf offer a focused review and update on the most recent advances in nuclear cardiovascular imaging of inflammation, infection, and infarct healing.Page 673
PET, Medicare, and coverage: Hillman reviews the efforts of the National Oncologic PET Registry in providing evidence of the beneficial effects of PET in patient management and previews an article on this topic in this issue of JNM.Page 677
PET and activated T lymphocytes: Gialleonardo and colleagues describe the development and 18F labeling of a PET compound for detection of interleukin 2–positive cells overexpressed on activated T lymphocytes.Page 679
PET/perfusion CT and colorectal cancer: Goh and colleagues use this hybrid approach to evaluate the in vivo flow–metabolic phenotype in primary colorectal cancer and compare the results with histopathologic assessment of angiogenesis and hypoxia.Page 687
PET tumor heterogeneity: Tixier and colleagues determine the reproducibility of heterogeneity measurements of standardized uptake values in 18F-FDG PET as metrics for monitoring therapy response and predicting outcome.Page 693
SUV repeatability in tumors: de Langen and colleagues report on a metaanalysis of the repeatability of different standardized uptake value measurements of 18F-FDG for monitoring tumor response to therapy.Page 701
MTV and TGA in oral cancers: Dibble and colleagues investigate whether 18F-FDG metabolic tumor volume and total glycolytic activity on PET add prognostic information to clinical staging in patients with oral and oropharyngeal squamous cell carcinomas.Page 709
99mTc-3PRGD2 and lung cancer: Zhu and colleagues detail the results of a multicenter study in patients with lung cancer to explore the efficacy of this novel angiogenesis-imaging SPECT tracer that targets integrin αVβ3 receptors in tumors.Page 716
TID and 82Rb PET MPI: Rischpler and colleagues explore the role of the transient ischemic dilation ratio, familiar in myocardial perfusion SPECT, as a diagnostic and prognostic marker in 82Rb PET cardiac imaging.Page 723
Anemia and 123I-MIBG in heart failure: Doi and colleagues examine prognostic implications of cardiac autonomic function assessed by 123I-MIBG activity, hemoglobin, and kidney function in patients with chronic heart failure.Page 731
Hepatobiliary transport PET: Takashima and colleagues look at hepatic uptake and subsequent canalicular efflux of an 11C-labeled anionic compound for PET kinetic analysis of normal transport function.Page 741
Amifostine and renal octreotate: Melis and colleagues describe studies evaluating the direct effect of the cytoprotective agent amifostine on rat kidney and tumor uptake of a peptide receptor radionuclide therapy agent.Page 749
Radioiodine scintigraphy with SPECT/CT: Avram offers an educational overview of progress in diagnostic and posttherapy thyroid cancer imaging with SPECT/CT technology and radioiodine scintigraphy and the implications for staging, risk stratification, and clinical management.Page 754
111In-RGD and pancreatic cancer: Yoshimoto and colleagues investigate the utility of SPECT with an αvβ3-integrin imaging probe for early detection in a hamster model of pancreatic carcinogenesis.Page 765
11C-cholylsarcosine PET: Frisch and colleagues describe the development and initial assessment of a novel bile acid PET tracer to evaluate hepatic excretory function.Page 772
Imaging VLA-4 in the premetastatic niche: Shokeen and colleagues detail experiments designed to advance imaging of very late antigen-4–positive bone marrow–derived cells using a 64Cu-labeled high-affinity PET probe.Page 779
Radiation dosimetry of 18F-RGD-K5: Doss and colleagues outline biodistribution and estimate radiation dose from this novel 18F-labeled αvβ3 integrin marker using whole-body PET/CT scans in monkeys and humans.Page 787
Four-class MRI AC for PET/MRI: Berker and colleagues describe an innovative tissue segmentation technique for MRI-based γ–photon attenuation correction for hybrid PET/MRI using a combined ultrashort–echo time/Dixon MRI sequence.Page 796
Exploring dopamine receptor abnormalities: Kuwabara and colleagues report on a bolus-plus-infusion transformation method and its validation in PET measurement of available receptor density and equilibrium dissociation constants in functional striatal subdivisions of the human brain.Page 805
11C-methylphenidate DAT imaging in rats: Sossi and colleagues investigate the characteristics of PET quantification of dopamine transporter function in a rat model of Parkinson disease.Page 813
O2 and 18F-FLT uptake: Fuchs and colleagues report on observed differences in dynamic and static PET measurements of 18F-FLT uptake in arthritic ankles and carcinomas in mice breathing oxygen.Page 823
NOPR 2006 and 2009 cohorts: Hillner and colleagues compare clinical profiles and changes in intended management at these 2 time points using data gathered under the National Oncologic PET Registry initiative.Page 831
ON THE COVER
In patients with thyroid cancer, diagnostic SPECT/CT has incremental value over planar whole-body scintigraphy. In the patient illustrated here, the planar static view shows 2 foci of activity. SPECT/CT clarifies that the left focus represents thyroid remnant tissue in the thyroidectomy bed, and the right focus corresponds to a nodal metastasis.See page 757.
- © 2012 by the Society of Nuclear Medicine, Inc.