Whole-Body HER2 Heterogeneity Identified on HER2 PET in HER2-Negative, -Low, and -Positive Metastatic Breast Cancer

Bertha Eisses; Jasper J.L. van Geel; Adrienne H. Brouwers; Frederike Bensch; Sjoerd G. Elias; Evelien J.M. Kuip; Agnes Jager; Bert van der Vegt; Marjolijn N. Lub-de Hooge; Jasper Emmering; Anne I.J. Arens; Gerben J.C. Zwezerijnen; Daniëlle J. Vugts; C. Willemien Menke-van der Houven van Oordt; Elisabeth G.E. de Vries; Carolina P. Schröder

doi:10.2967/jnumed.124.267636

Research ArticleClinical Investigation

Whole-Body HER2 Heterogeneity Identified on HER2 PET in HER2-Negative, -Low, and -Positive Metastatic Breast Cancer

Bertha Eisses, Jasper J.L. van Geel, Adrienne H. Brouwers, Frederike Bensch, Sjoerd G. Elias, Evelien J.M. Kuip, Agnes Jager, Bert van der Vegt, Marjolijn N. Lub-de Hooge, Jasper Emmering, Anne I.J. Arens, Gerben J.C. Zwezerijnen, Daniëlle J. Vugts, C. Willemien Menke-van der Houven van Oordt, Elisabeth G.E. de Vries and Carolina P. Schröder

Journal of Nuclear Medicine September 2024, jnumed.124.267636; DOI: https://doi.org/10.2967/jnumed.124.267636

Bertha Eisses

1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;

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Jasper J.L. van Geel

1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;

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Adrienne H. Brouwers

2Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, the Netherland;

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Frederike Bensch

1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;

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Sjoerd G. Elias

3Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands;

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Evelien J.M. Kuip

4Department of Medical Oncology, Radboud Medical Center, Nijmegen, The Netherlands;

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Agnes Jager

5Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands;

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Bert van der Vegt

6Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;

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Marjolijn N. Lub-de Hooge

2Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, the Netherland;

7Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;

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Jasper Emmering

8Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands;

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Anne I.J. Arens

9Department of Radiology and Nuclear Medicine, Radboud Medical Center, Nijmegen, The Netherlands;

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Gerben J.C. Zwezerijnen

10Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, The Netherlands;

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Daniëlle J. Vugts

10Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, The Netherlands;

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C. Willemien Menke-van der Houven van Oordt

11Department of Medical Oncology and Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; and

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Elisabeth G.E. de Vries

1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;

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Carolina P. Schröder

1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;

12Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands

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Vol. 65, Issue 10

October 1, 2024

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Whole-Body HER2 Heterogeneity Identified on HER2 PET in HER2-Negative, -Low, and -Positive Metastatic Breast Cancer

Journal of Nuclear Medicine Sep 2024, jnumed.124.267636; DOI: 10.2967/jnumed.124.267636

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Whole-Body HER2 Heterogeneity Identified on HER2 PET in HER2-Negative, -Low, and -Positive Metastatic Breast Cancer

Journal of Nuclear Medicine Sep 2024, jnumed.124.267636; DOI: 10.2967/jnumed.124.267636

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Keywords

breast cancer
metastases
human epidermal receptor 2
HER2
89Zr-trastuzumab PET
diagnostic performance

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