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OtherBasic Science (Animal or Phantoms)
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Substitution of L-Trp by α-methyl-L-Trp in 177Lu-RM2 results in 177Lu-AMTG, a high affinity GRPR ligand with improved in vivo stability

Thomas Guenther, Sandra Deiser, Veronika Felber, Roswitha Beck and Hans-Juergen Wester
Journal of Nuclear Medicine January 2022, jnumed.121.263323; DOI: https://doi.org/10.2967/jnumed.121.263323
Thomas Guenther
Technical University of Munich, Germany
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Sandra Deiser
Technical University of Munich, Germany
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Veronika Felber
Technical University of Munich, Germany
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Roswitha Beck
Technical University of Munich, Germany
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Hans-Juergen Wester
Technical University of Munich, Germany
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Journal of Nuclear Medicine: 64 (10)
Journal of Nuclear Medicine
Vol. 64, Issue 10
October 1, 2023
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Substitution of L-Trp by α-methyl-L-Trp in 177Lu-RM2 results in 177Lu-AMTG, a high affinity GRPR ligand with improved in vivo stability
Thomas Guenther, Sandra Deiser, Veronika Felber, Roswitha Beck, Hans-Juergen Wester
Journal of Nuclear Medicine Jan 2022, jnumed.121.263323; DOI: 10.2967/jnumed.121.263323

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Substitution of L-Trp by α-methyl-L-Trp in 177Lu-RM2 results in 177Lu-AMTG, a high affinity GRPR ligand with improved in vivo stability
Thomas Guenther, Sandra Deiser, Veronika Felber, Roswitha Beck, Hans-Juergen Wester
Journal of Nuclear Medicine Jan 2022, jnumed.121.263323; DOI: 10.2967/jnumed.121.263323
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Keywords

  • Peptides
  • radionuclide therapy
  • radiopharmaceuticals
  • AMTG
  • GRPR
  • RM2
  • increased metabolic stability
  • prostate cancer
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