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Journal of Nuclear Medicine

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OtherMI Focus (Invitation Only)

Molecular Imaging: PARP-1 and Beyond

Laura Puentes, Mehran Makvandi and Robert Henry Mach
Journal of Nuclear Medicine February 2021, jnumed.120.243287; DOI: https://doi.org/10.2967/jnumed.120.243287
Laura Puentes
University of Pennsylvania, United States
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Mehran Makvandi
University of Pennsylvania, United States
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Robert Henry Mach
University of Pennsylvania, United States
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Abstract

The genetic code to life is balanced on a string of DNA that is under constant metabolic and physical stress from environmental forces. Nearly all diseases have a genetic component caused by or resulting in DNA damage that alters biology to drive pathogenesis. Recent advancements in DNA repair biology have led to the development of imaging tools that target DNA damage response and repair proteins. Positron-emission tomography (PET) has been used for early detection of oncogenic processes and monitoring tumor response to chemotherapeutics that target the DNA repair machinery. In the field of precision medicine, imaging tools provide a unique opportunity for patient stratification by directly measuring drug target expression or monitoring therapy to identify early responders. This overview discusses the state-of-the-art on molecular imaging of DNA damage and repair from the past 5 years, with an emphasis on poly [adenosine diphosphate (ADP) ribose] polymerase-1 (PARP-1) as an imaging target and predictive biomarker of response to therapy.

  • Molecular Imaging
  • PET/CT
  • Radiopharmaceuticals
  • DNA
  • PARP-1
  • imaging
  • Copyright © 2021 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

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Journal of Nuclear Medicine: 62 (3)
Journal of Nuclear Medicine
Vol. 62, Issue 3
March 1, 2021
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Molecular Imaging: PARP-1 and Beyond
Laura Puentes, Mehran Makvandi, Robert Henry Mach
Journal of Nuclear Medicine Feb 2021, jnumed.120.243287; DOI: 10.2967/jnumed.120.243287

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Molecular Imaging: PARP-1 and Beyond
Laura Puentes, Mehran Makvandi, Robert Henry Mach
Journal of Nuclear Medicine Feb 2021, jnumed.120.243287; DOI: 10.2967/jnumed.120.243287
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Keywords

  • molecular imaging
  • PET/CT
  • radiopharmaceuticals
  • DNA
  • PARP-1
  • imaging
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