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OtherClinical Investigations (Human)

The impact of monosodium glutamate on 68Ga-PSMA-11 biodistribution in men with prostate cancer: a prospective randomized, controlled, imaging study

Wesley Robert Armstrong, Andrei Gafita, Shaojun Zhu, Pan Thin, Kathleen Nguyen, Rejah Marie Alano, Stephanie Lira, Kiara Booker, Linda Gardner, Tristan Grogan, David Elashoff, Martin S. Allen-Auerbach, Magnus S. Dahlbom, Johannes Czernin and Jérémie Calais
Journal of Nuclear Medicine January 2021, jnumed.120.257931; DOI: https://doi.org/10.2967/jnumed.120.257931
Wesley Robert Armstrong
1 University of California Los Angeles, United States;
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Andrei Gafita
1 University of California Los Angeles, United States;
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Shaojun Zhu
1 University of California Los Angeles, United States;
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Pan Thin
1 University of California Los Angeles, United States;
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Kathleen Nguyen
1 University of California Los Angeles, United States;
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Rejah Marie Alano
1 University of California Los Angeles, United States;
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Stephanie Lira
1 University of California Los Angeles, United States;
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Kiara Booker
1 University of California Los Angeles, United States;
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Linda Gardner
1 University of California Los Angeles, United States;
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Tristan Grogan
1 University of California Los Angeles, United States;
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David Elashoff
1 University of California Los Angeles, United States;
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Martin S. Allen-Auerbach
1 University of California Los Angeles, United States;
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Magnus S. Dahlbom
2 UCLA School of Medicine
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Johannes Czernin
2 UCLA School of Medicine
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Jérémie Calais
1 University of California Los Angeles, United States;
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Abstract

Background: The prostate-specific membrane antigen (PSMA) has been targeted for PET imaging and radioligand therapy (RLT) in patients with prostate cancer. Xerostomia is a common side effect of RLT due to high salivary gland uptake of PSMA-radioligands. Here we aimed to determine the impact of monosodium glutamate (MSG) administration on PSMA-radioligand biodistribution within healthy organs and tumor lesions by using 68Ga-PSMA-11 PET imaging. Methods: 16 men with prostate cancer were randomized (1:1) into oral ingestion and oral topical application (‘swishing’) arms. Each subject underwent two 68Ga-PSMA-11 PET/CT scans within 14 days under baseline and MSG conditions. Salivary glands and whole-body tumor lesions were segmented using qPSMA software. We quantified tracer uptake via mean and maximum standardized uptake values (SUVmean and SUVmax) and compared parameters within each patient. Results: For the oral ingestion arm, salivary gland SUVmean/max decreased on average from Control to MSG scan by 45±15% (P = 0.004) and 53±11% (p<0.001), respectively. Tumor lesions SUVmean/ max also decreased by 38% (IQR -67%, -33%) and -52% (IQR -70%, -49%), respectively (P = 0.018). Swishing had no significant effect on 68Ga-PSMA-11 accumulation in normal organs or tumor lesions. Conclusion: Oral ingestion but not topical application of MSG reduced 68Ga-PSMA-11 uptake in salivary glands. Tumor uptake also declined, therefore, the clinical application of MSG is unlikely to be useful in the framework of RLT.

  • Oncology: GU
  • PET/CT
  • Radionuclide Therapy
  • Monosodium glutamate
  • PET/CT
  • PSMA
  • salivary glands
  • xerostomia
  • Copyright © 2021 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

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Journal of Nuclear Medicine: 62 (3)
Journal of Nuclear Medicine
Vol. 62, Issue 3
March 1, 2021
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The impact of monosodium glutamate on 68Ga-PSMA-11 biodistribution in men with prostate cancer: a prospective randomized, controlled, imaging study
Wesley Robert Armstrong, Andrei Gafita, Shaojun Zhu, Pan Thin, Kathleen Nguyen, Rejah Marie Alano, Stephanie Lira, Kiara Booker, Linda Gardner, Tristan Grogan, David Elashoff, Martin S. Allen-Auerbach, Magnus S. Dahlbom, Johannes Czernin, Jérémie Calais
Journal of Nuclear Medicine Jan 2021, jnumed.120.257931; DOI: 10.2967/jnumed.120.257931

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The impact of monosodium glutamate on 68Ga-PSMA-11 biodistribution in men with prostate cancer: a prospective randomized, controlled, imaging study
Wesley Robert Armstrong, Andrei Gafita, Shaojun Zhu, Pan Thin, Kathleen Nguyen, Rejah Marie Alano, Stephanie Lira, Kiara Booker, Linda Gardner, Tristan Grogan, David Elashoff, Martin S. Allen-Auerbach, Magnus S. Dahlbom, Johannes Czernin, Jérémie Calais
Journal of Nuclear Medicine Jan 2021, jnumed.120.257931; DOI: 10.2967/jnumed.120.257931
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Clinical Investigations (Human)

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Clinical (Oncology: GU)

  • Prospective, Single-Arm Trial Evaluating Changes in Uptake Patterns on Prostate-Specific Membrane Antigen (PSMA)-Targeted 18F-DCFPyL PET/CT in Patients with Castration-Resistant Prostate Cancer Starting Abiraterone or Enzalutamide
  • Matched-pair comparison of 18F-DCFPyL PET/CT and 18F-PSMA-1007 PET/CT in 240 prostate cancer patients; inter-reader agreement and lesion detection rate of suspected lesions
  • Combination of forced diuresis with additional late imaging in 68Ga-PSMA-11 PET/CT – effects on lesion visibility and radiotracer uptake
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Keywords

  • Oncology: GU
  • PET/CT
  • Radionuclide Therapy
  • Monosodium glutamate
  • PSMA
  • salivary glands
  • xerostomia
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