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Journal of Nuclear Medicine

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OtherBrief Communication

Imaging calreticulin for early detection of immunogenic cell death during anticancer treatment

Dong-Yeon Kim, Ayoung Pyo, Misun Yun, Ramar Thangam, Sung-Hwan You, Ying Zhang, Ye-rim Jung, Dinh-Huy Nguyen, Akhil Venu, Hyeon Sik Kim, Mee Sun Yoon, Yeongjin Hong and Jung-Joon Min
Journal of Nuclear Medicine January 2021, jnumed.120.245290; DOI: https://doi.org/10.2967/jnumed.120.245290
Dong-Yeon Kim
1 College of Pharmacy and Research Institute of Pharmaceutical Science, Gyeongsang National University, Korea, Republic of;
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Ayoung Pyo
2 Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, Korea, Republic of;
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Misun Yun
3 World Institute of Kimchi, Korea, Republic of;
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Ramar Thangam
2 Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, Korea, Republic of;
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Sung-Hwan You
2 Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, Korea, Republic of;
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Ying Zhang
2 Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, Korea, Republic of;
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Ye-rim Jung
2 Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, Korea, Republic of;
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Dinh-Huy Nguyen
2 Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, Korea, Republic of;
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Akhil Venu
2 Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, Korea, Republic of;
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Hyeon Sik Kim
4 Korea Photonics Technology Institute, Korea, Republic of;
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Mee Sun Yoon
5 Chonnam National University Hwasun Hospital, Korea, Republic of;
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Yeongjin Hong
6 Chonnam National University Medical School, Korea, Republic of;
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Jung-Joon Min
7 Chonnam National University Medical School and Hwasun Hospital, Korea, Republic of
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Abstract

Surface-exposed calreticulin (ecto-CRT) is a well-known ‘eat-me’ signal exhibited by dying cells that contributes to their recognition and destruction by the immune system. We assessed the use of a CRT-specific binding peptide for imaging ecto-CRT during immunogenic cell death and its utility for the early prediction of treatment response. Methods: A synthetic CRT-specific peptide KLGFFKR (CRTpep) was labeled with fluorescein isothiocyanate or 18F and characteristics of ecto-CRT was evaluated in colon cancer cell line in vitro and in vivo. Results: In vitro flow cytometry, immunofluorescence staining, and in vivo micro positron emission tomography imaging results showed that CRTpep detected pre-apoptotic cells treated with immunogenic drugs or radiation, but not those treated with the non-immunogenic drug or a non-therapeutic dose of immunogenic drug. Conclusion: The present results indicate that the CRT-specific peptide would enable the prediction of therapeutic response, thereby facilitating early decisions regarding the continuation or discontinuation of immunogenic treatment.

  • Animal Imaging
  • Molecular Imaging
  • PET
  • Calreticulin
  • Immunogenic cell death
  • Molecular imaging
  • Positron Emission Tomography
  • Therapy response
  • Copyright © 2021 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

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Journal of Nuclear Medicine: 62 (3)
Journal of Nuclear Medicine
Vol. 62, Issue 3
March 1, 2021
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Imaging calreticulin for early detection of immunogenic cell death during anticancer treatment
Dong-Yeon Kim, Ayoung Pyo, Misun Yun, Ramar Thangam, Sung-Hwan You, Ying Zhang, Ye-rim Jung, Dinh-Huy Nguyen, Akhil Venu, Hyeon Sik Kim, Mee Sun Yoon, Yeongjin Hong, Jung-Joon Min
Journal of Nuclear Medicine Jan 2021, jnumed.120.245290; DOI: 10.2967/jnumed.120.245290

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Imaging calreticulin for early detection of immunogenic cell death during anticancer treatment
Dong-Yeon Kim, Ayoung Pyo, Misun Yun, Ramar Thangam, Sung-Hwan You, Ying Zhang, Ye-rim Jung, Dinh-Huy Nguyen, Akhil Venu, Hyeon Sik Kim, Mee Sun Yoon, Yeongjin Hong, Jung-Joon Min
Journal of Nuclear Medicine Jan 2021, jnumed.120.245290; DOI: 10.2967/jnumed.120.245290
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Keywords

  • Animal Imaging
  • molecular imaging
  • PET
  • Calreticulin
  • Immunogenic cell death
  • Positron Emission Tomography
  • Therapy response
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