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Journal of Nuclear Medicine

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OtherClinical Investigations (Human)
Open Access

PET/CT guided biopsy of suspected lung lesions requires less rebiopsy than CT guided biopsy due to inconclusive results

Juliano J. Cerci, Mateos Bogoni, Rodrigo J. Cerci, Margaret Masukawa, Carlos C. P. Neto, Cassiano Krauzer, Stefano Fanti, Danielle G. Sakamoto, Renan B. Barreiros, Cristina Nanni and João V. Vitola
Journal of Nuclear Medicine December 2020, jnumed.120.252403; DOI: https://doi.org/10.2967/jnumed.120.252403
Juliano J. Cerci
1 PET/CT Department - Quanta Diagnóstico e Terapia, Curitiba - Brazil, Brazil;
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Mateos Bogoni
1 PET/CT Department - Quanta Diagnóstico e Terapia, Curitiba - Brazil, Brazil;
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Rodrigo J. Cerci
1 PET/CT Department - Quanta Diagnóstico e Terapia, Curitiba - Brazil, Brazil;
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Margaret Masukawa
1 PET/CT Department - Quanta Diagnóstico e Terapia, Curitiba - Brazil, Brazil;
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Carlos C. P. Neto
1 PET/CT Department - Quanta Diagnóstico e Terapia, Curitiba - Brazil, Brazil;
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Cassiano Krauzer
1 PET/CT Department - Quanta Diagnóstico e Terapia, Curitiba - Brazil, Brazil;
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Stefano Fanti
2 Nuclear Medicine Department - University Hospital S.Orsola-Malpighi, Bologna - Italy;
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Danielle G. Sakamoto
3 Byori - Laboratório de Patologia, Curitiba - Brazil;
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Renan B. Barreiros
4 Hospital de Clínicas da Universidade Federal do Paraná - Brazil
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Cristina Nanni
2 Nuclear Medicine Department - University Hospital S.Orsola-Malpighi, Bologna - Italy;
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João V. Vitola
1 PET/CT Department - Quanta Diagnóstico e Terapia, Curitiba - Brazil, Brazil;
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Abstract

The purpose of this study is to compare FDG PET/CT and CT performance in guiding percutaneous biopsies with histological confirmation of lung lesions. Methods: We prospectively evaluated 341 patients of whom 216 underwent FDG PET/CT-guided biopsy and 125 underwent CT-guided biopsy. The pathology results, lesion size, complications and rebiopsy rate in the two groups were evaluated. Results: Of the 216 biopsies with PET/CT guidance, histology demonstrated 170 lesions (78.7%) to be malignant, and 46 (21.3%) to be benign; In the CT guided group, out of 125 lesions, 77 (61.6%) were malignant and 48 (38.4%) were benign (p = 0.001). Inconclusive results prompted the need for a second biopsy in 18 patients, 13/125 (10.4%) in the CT group and 5 /216 (2.3%) in PET group (p 0.001). Complications rates were: pneumothorax (13.2%), hemothorax (0.8%) and hemoptysis (0.6%). No life-threatening adverse events or fatalities were reported. The difference between complication rates among the 2 groups was not significant (P = 0.6). Malignant lesions showed greater mean size than benign lesions regardless of the group (P = 0.015). Conclusion: PET/CT guided biopsy of lung lesions led to fewer inconclusive biopsies in comparison with CT guided biopsy, with similar complication rates.

  • Oncology: Lung
  • CT-guided biopsy
  • FDG PET/CT
  • Lung Cancer
  • PET/CT-guided biopsy.
  • Copyright © 2020 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

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Journal of Nuclear Medicine: 62 (2)
Journal of Nuclear Medicine
Vol. 62, Issue 2
February 1, 2021
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PET/CT guided biopsy of suspected lung lesions requires less rebiopsy than CT guided biopsy due to inconclusive results
Juliano J. Cerci, Mateos Bogoni, Rodrigo J. Cerci, Margaret Masukawa, Carlos C. P. Neto, Cassiano Krauzer, Stefano Fanti, Danielle G. Sakamoto, Renan B. Barreiros, Cristina Nanni, João V. Vitola
Journal of Nuclear Medicine Dec 2020, jnumed.120.252403; DOI: 10.2967/jnumed.120.252403

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PET/CT guided biopsy of suspected lung lesions requires less rebiopsy than CT guided biopsy due to inconclusive results
Juliano J. Cerci, Mateos Bogoni, Rodrigo J. Cerci, Margaret Masukawa, Carlos C. P. Neto, Cassiano Krauzer, Stefano Fanti, Danielle G. Sakamoto, Renan B. Barreiros, Cristina Nanni, João V. Vitola
Journal of Nuclear Medicine Dec 2020, jnumed.120.252403; DOI: 10.2967/jnumed.120.252403
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Keywords

  • Oncology: Lung
  • CT-guided biopsy
  • FDG PET/CT
  • lung cancer
  • PET/CT-guided biopsy.
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