OtherMI Focus (Invitation Only)
What is T+? A Gordian Knot of Tracers, Thresholds & Topographies
Victor L. Villemagne, Brian J. Lopresti, Vincent Dore, Dana Tudorascu, Milos D. Ikonomovic, Samantha Burnham, Davneet Minhas, Tharick A. Pascoal, N. Scott Mason, Beth Snitz, Howard Aizenstein, Chester A. Mathis, Oscar Lopez, Christopher C. Rowe, William E. Klunk and Ann D. Cohen
Journal of Nuclear Medicine December 2020, jnumed.120.245423; DOI: https://doi.org/10.2967/jnumed.120.245423
Victor L. Villemagne
1 Department of Psychiatry, University of Pittsburgh, United States;
Brian J. Lopresti
2 Department of Radiology, University of Pittsburgh School of Medicine;
Vincent Dore
3 CSIRO Health & Biosecurity, Melbourne, Victoria, Australia;
Dana Tudorascu
4 Department of Psychiatry, University of Pittsburgh School of Medicine;
Milos D. Ikonomovic
5 Department of Neurology, University of Pittsburgh School of Medicine;
Samantha Burnham
3 CSIRO Health & Biosecurity, Melbourne, Victoria, Australia;
Davneet Minhas
2 Department of Radiology, University of Pittsburgh School of Medicine;
Tharick A. Pascoal
4 Department of Psychiatry, University of Pittsburgh School of Medicine;
N. Scott Mason
2 Department of Radiology, University of Pittsburgh School of Medicine;
Beth Snitz
4 Department of Psychiatry, University of Pittsburgh School of Medicine;
Howard Aizenstein
4 Department of Psychiatry, University of Pittsburgh School of Medicine;
Chester A. Mathis
2 Department of Radiology, University of Pittsburgh School of Medicine;
Oscar Lopez
4 Department of Psychiatry, University of Pittsburgh School of Medicine;
Christopher C. Rowe
6 Department of Molecular Imaging & Therapy, Austin Health, Melbourne, VIC, Australia
William E. Klunk
4 Department of Psychiatry, University of Pittsburgh School of Medicine;
Ann D. Cohen
4 Department of Psychiatry, University of Pittsburgh School of Medicine;
Abstract
In this review we examine, in the context of the AT(N) framework, the available evidence as well as the potential alternatives on how to establish tau-positivity (T+) for multiple tau imaging tracers in order to come to a consensus for “normal” and “abnormal” tau imaging values that can be universally implemented in clinical research and therapeutic trials.
- Copyright © 2020 by the Society of Nuclear Medicine and Molecular Imaging, Inc.
In this issue
Journal of Nuclear Medicine
Vol. 66, Issue 1
January 1, 2025
What is T+? A Gordian Knot of Tracers, Thresholds & Topographies
Victor L. Villemagne, Brian J. Lopresti, Vincent Dore, Dana Tudorascu, Milos D. Ikonomovic, Samantha Burnham, Davneet Minhas, Tharick A. Pascoal, N. Scott Mason, Beth Snitz, Howard Aizenstein, Chester A. Mathis, Oscar Lopez, Christopher C. Rowe, William E. Klunk, Ann D. Cohen
Journal of Nuclear Medicine Dec 2020, jnumed.120.245423; DOI: 10.2967/jnumed.120.245423
What is T+? A Gordian Knot of Tracers, Thresholds & Topographies
Victor L. Villemagne, Brian J. Lopresti, Vincent Dore, Dana Tudorascu, Milos D. Ikonomovic, Samantha Burnham, Davneet Minhas, Tharick A. Pascoal, N. Scott Mason, Beth Snitz, Howard Aizenstein, Chester A. Mathis, Oscar Lopez, Christopher C. Rowe, William E. Klunk, Ann D. Cohen
Journal of Nuclear Medicine Dec 2020, jnumed.120.245423; DOI: 10.2967/jnumed.120.245423
Jump to section
Related Articles
Cited By...
- Differential effects of aging, Alzheimers pathology, and APOE4 on longitudinal functional connectivity and episodic memory in older adults
- Improved Correlation of 18F-Flortaucipir PET SUVRs and Clinical Stages in the Alzheimer Disease Continuum with the MUBADA/PERSI-Based Analysis
- Plasma p-tau217 predicts cognitive impairments up to ten years before onset in normal older adults
- CenTauR: Towards a Universal Scale and Masks for Standardizing Tau Imaging Studies
- Tau PET Imaging in Neurodegenerative Disorders
- AT(N) predicts near-term development of Alzheimers disease symptoms in unimpaired older adults
- Tau Imaging with 18F-MK6240 across the Alzheimers Disease spectrum