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Overview of the First NRG-NCI Workshop on Dosimetry of Systemic Radiopharmaceutical Therapy (RPT)

Emilie Roncali, Jacek Capala, Stanley H Benedict, Gamal Akabani, Bryan Bednarz, Vikram Bhadrasain, Wesley E. Bolch, Jeff Buchsbaum, Bonnie N. Clarke, Norman Coleman, Yuni K Dewaraja, Eric C. Frey, Michael Ghaly, Joseph Grudzinski, Robert F Hobbs, Roger W. Howell, John Laurence Humm, Charles Kunos, Steven M. Larson, Frank I Lin, Mark T. Madsen, Saed Mirzadeh, David L. Morse, Daniel A Pryma, George Sgouros, Sara St. James, Richard L. Wahl, Ying Xiao, Pat B. Zanzonico and Katherine B. Zukotynski
Journal of Nuclear Medicine December 2020, jnumed.120.255547; DOI: https://doi.org/10.2967/jnumed.120.255547
Emilie Roncali
1 UC Davis;
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Jacek Capala
2 National Institutes of Health, Department of Health and Human Services;
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Stanley H Benedict
3 University of California at Davis, United States;
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Gamal Akabani
4 Texas A&M University;
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Bryan Bednarz
5 University of Wisconsin - Madison;
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Vikram Bhadrasain
6 National Institutes of Health;
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Wesley E. Bolch
7 University of Florida;
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Jeff Buchsbaum
6 National Institutes of Health;
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Bonnie N. Clarke
8 SNMMI;
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Norman Coleman
6 National Institutes of Health;
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Yuni K Dewaraja
9 University of Michigan;
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Eric C. Frey
10 Johns Hopkins Medical Institutions;
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Michael Ghaly
10 Johns Hopkins Medical Institutions;
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Joseph Grudzinski
11 University of Wisconsin, Madison, WI;
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Robert F Hobbs
12 Johns Hopkins University;
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Roger W. Howell
13 Rutgers New Jersey Medical School;
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John Laurence Humm
14 Memorial Sloan-Kettering Cancer Center;
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Charles Kunos
6 National Institutes of Health;
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Steven M. Larson
14 Memorial Sloan-Kettering Cancer Center;
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Frank I Lin
6 National Institutes of Health;
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Mark T. Madsen
15 University of Iowa;
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Saed Mirzadeh
16 Oak Ridge National Laboratory;
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David L. Morse
17 H. Lee Moffitt Cancer Center & Research Institute;
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Daniel A Pryma
18 University of Pennsylvania;
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George Sgouros
19 Johns Hopkins University, School of Medicine;
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Sara St. James
20 UCSF;
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Richard L. Wahl
21 Mallinckrodt Institute of Radiology;
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Ying Xiao
22 U. Pennsylvania;
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Pat B. Zanzonico
14 Memorial Sloan-Kettering Cancer Center;
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Katherine B. Zukotynski
23 McMaster University
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Abstract

In 2018, the National Cancer Institute (NCI) and the NRG Oncology partnered for the first time to host a joint Workshop on Systemic Radiopharmaceutical Therapy (RPT) to specifically address issues and strategies of dosimetry for future clinical trials. The workshop focused on (1) current dosimetric approaches for clinical trials, (2) strategies under development that would provide optimal dose reporting, and (3) future desired/optimized approaches for the new and novel emerging radionuclides and carriers in development. In this proceedings, we review the main approaches that are applied clinically to calculate the absorbed dose: These include absorbed doses calculated over a variety of spatial scales including organ, suborgan, and voxel, all achievable within the Medical Internal Radiation Dose (MIRD) schema (S-value) can be calculated with analytic methods or Monte Carlo methods, the latter in most circumstances. This proceeding will also contrast currently available methods and tools with those used in the past, to propose a pathway whereby dosimetry helps the field by optimizing the biological effect of the treatment and trial design in the drug approval process to reduce financial and logistical costs. We will also discuss the dosimetric equivalent of biomarkers to help bring a precision medicine approach to RPT implementation-when merited by evidence collected during early-phase trial investigations. Advances in the methodology and related tools have made dosimetry the optimum biomarker for RPT.

  • Radiobiology/Dosimetry
  • Radionuclide Therapy
  • Radiopharmaceuticals
  • Cellular dosimetry
  • Dosimetry
  • Microdosimetry
  • Radiopharmaceutical Therapy (RPT)
  • Targeted radionuclide Therapy
  • Copyright © 2020 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

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Journal of Nuclear Medicine: 62 (2)
Journal of Nuclear Medicine
Vol. 62, Issue 2
February 1, 2021
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Overview of the First NRG-NCI Workshop on Dosimetry of Systemic Radiopharmaceutical Therapy (RPT)
Emilie Roncali, Jacek Capala, Stanley H Benedict, Gamal Akabani, Bryan Bednarz, Vikram Bhadrasain, Wesley E. Bolch, Jeff Buchsbaum, Bonnie N. Clarke, Norman Coleman, Yuni K Dewaraja, Eric C. Frey, Michael Ghaly, Joseph Grudzinski, Robert F Hobbs, Roger W. Howell, John Laurence Humm, Charles Kunos, Steven M. Larson, Frank I Lin, Mark T. Madsen, Saed Mirzadeh, David L. Morse, Daniel A Pryma, George Sgouros, Sara St. James, Richard L. Wahl, Ying Xiao, Pat B. Zanzonico, Katherine B. Zukotynski
Journal of Nuclear Medicine Dec 2020, jnumed.120.255547; DOI: 10.2967/jnumed.120.255547

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Overview of the First NRG-NCI Workshop on Dosimetry of Systemic Radiopharmaceutical Therapy (RPT)
Emilie Roncali, Jacek Capala, Stanley H Benedict, Gamal Akabani, Bryan Bednarz, Vikram Bhadrasain, Wesley E. Bolch, Jeff Buchsbaum, Bonnie N. Clarke, Norman Coleman, Yuni K Dewaraja, Eric C. Frey, Michael Ghaly, Joseph Grudzinski, Robert F Hobbs, Roger W. Howell, John Laurence Humm, Charles Kunos, Steven M. Larson, Frank I Lin, Mark T. Madsen, Saed Mirzadeh, David L. Morse, Daniel A Pryma, George Sgouros, Sara St. James, Richard L. Wahl, Ying Xiao, Pat B. Zanzonico, Katherine B. Zukotynski
Journal of Nuclear Medicine Dec 2020, jnumed.120.255547; DOI: 10.2967/jnumed.120.255547
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Keywords

  • Radiobiology/Dosimetry
  • Radionuclide Therapy
  • radiopharmaceuticals
  • Cellular dosimetry
  • dosimetry
  • Microdosimetry
  • Radiopharmaceutical Therapy (RPT)
  • targeted radionuclide therapy
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