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Journal of Nuclear Medicine

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OtherBasic Science (Animal or Phantoms)

Optoacoustic imaging of Glucagon-like Peptide 1 Receptor with a near-infrared exendin-4 analog

Sheryl Roberts, Eshita Khera, Crystal Choi, Tejas Navaratna, Jan Grimm, Greg M. Thurber and Thomas Reiner
Journal of Nuclear Medicine October 2020, jnumed.120.252262; DOI: https://doi.org/10.2967/jnumed.120.252262
Sheryl Roberts
1 Memorial Sloan Kettering Cancer Center, United States;
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Eshita Khera
2 University of Michigan, United States
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Crystal Choi
1 Memorial Sloan Kettering Cancer Center, United States;
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Tejas Navaratna
2 University of Michigan, United States
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Jan Grimm
1 Memorial Sloan Kettering Cancer Center, United States;
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Greg M. Thurber
2 University of Michigan, United States
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Thomas Reiner
1 Memorial Sloan Kettering Cancer Center, United States;
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Abstract

Limitations in current imaging tools have long challenged the imaging of small pancreatic islets in animal models. Here, we report the first development and in vivo validation testing of a broad spectrum and high absorbance near infrared optoacoustic contrast agent, E4x12-Cy7. Our near infrared tracer (E4x12-Cy7) is based on the amino acid sequence of exendin-4 and targets the glucagon-like peptide-1 receptor (GLP-1R). Cell assays confirmed that E4x12-Cy7 has a high binding affinity (IC50 = 4.6 ± 0.8 nM). Using the multi-spectral optoacoustic tomography (MSOT), we imaged E4x12-Cy7 and optoacoustically visualized β-cell insulinoma xenografts in vivo for the first time. In the future, similar optoacoustic tracers that are specific for β-cells and combines optoacoustic and fluorescence imaging modalities could prove to be important tools for monitoring the pancreas for the progression of diabetes.

  • Animal Imaging
  • Molecular Imaging
  • Other
  • MSOT
  • exendin-4
  • optoacoustic
  • sonophore
  • ß-cell mass
  • Copyright © 2020 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

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Journal of Nuclear Medicine: 62 (3)
Journal of Nuclear Medicine
Vol. 62, Issue 3
March 1, 2021
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Optoacoustic imaging of Glucagon-like Peptide 1 Receptor with a near-infrared exendin-4 analog
Sheryl Roberts, Eshita Khera, Crystal Choi, Tejas Navaratna, Jan Grimm, Greg M. Thurber, Thomas Reiner
Journal of Nuclear Medicine Oct 2020, jnumed.120.252262; DOI: 10.2967/jnumed.120.252262

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Optoacoustic imaging of Glucagon-like Peptide 1 Receptor with a near-infrared exendin-4 analog
Sheryl Roberts, Eshita Khera, Crystal Choi, Tejas Navaratna, Jan Grimm, Greg M. Thurber, Thomas Reiner
Journal of Nuclear Medicine Oct 2020, jnumed.120.252262; DOI: 10.2967/jnumed.120.252262
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Keywords

  • Animal Imaging
  • molecular imaging
  • Other
  • MSOT
  • exendin-4
  • optoacoustic
  • sonophore
  • ß-cell mass
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