Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model

Christian Sacher; Tanja Blume; Leonie Beyer; Finn Peters; Florian Eckenweber; Carmelo Sgobio; Maximilian Deussing; Nathalie Lisa Albert; Marcus Unterrainer; Simon Lindner; Franz-Josef Gildehaus; Barbara von Ungern-Sternberg; Irena Brzak; Ulf Neumann; Takashi Saito; Takaomi C. Saido; Peter Bartenstein; Axel Rominger; Jochen Herms; Matthias Brendel

doi:10.2967/jnumed.119.227322

OtherBasic Science (Animal or Phantoms)

Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model

Christian Sacher, Tanja Blume, Leonie Beyer, Finn Peters, Florian Eckenweber, Carmelo Sgobio, Maximilian Deussing, Nathalie Lisa Albert, Marcus Unterrainer, Simon Lindner, Franz-Josef Gildehaus, Barbara von Ungern-Sternberg, Irena Brzak, Ulf Neumann, Takashi Saito, Takaomi C. Saido, Peter Bartenstein, Axel Rominger, Jochen Herms and Matthias Brendel

Journal of Nuclear Medicine July 2019, jnumed.119.227322; DOI: https://doi.org/10.2967/jnumed.119.227322

Christian Sacher

1 Department of Nuclear Medicine, LMU Munich;

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Tanja Blume

1 Department of Nuclear Medicine, LMU Munich;

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Leonie Beyer

1 Department of Nuclear Medicine, LMU Munich;

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Finn Peters

2 German Center for Neurodegenerative Diseases (DZNE), Site Munich;

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Florian Eckenweber

1 Department of Nuclear Medicine, LMU Munich;

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Carmelo Sgobio

2 German Center for Neurodegenerative Diseases (DZNE), Site Munich;

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Maximilian Deussing

1 Department of Nuclear Medicine, LMU Munich;

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Nathalie Lisa Albert

1 Department of Nuclear Medicine, LMU Munich;

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Marcus Unterrainer

1 Department of Nuclear Medicine, LMU Munich;

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Simon Lindner

1 Department of Nuclear Medicine, LMU Munich;

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Franz-Josef Gildehaus

1 Department of Nuclear Medicine, LMU Munich;

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Barbara von Ungern-Sternberg

1 Department of Nuclear Medicine, LMU Munich;

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Irena Brzak

3 Neuroscience, Novartis Institutes for BioMedical Research (NIBR);

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Ulf Neumann

3 Neuroscience, Novartis Institutes for BioMedical Research (NIBR);

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Takashi Saito

4 Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science;

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Takaomi C. Saido

4 Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science;

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Peter Bartenstein

1 Department of Nuclear Medicine, LMU Munich;

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Axel Rominger

5 Department of Nuclear Medicine, Inselspital, University Hospital Bern;

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Jochen Herms

2 German Center for Neurodegenerative Diseases (DZNE), Site Munich;

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Matthias Brendel

6 Klinikum der Universität München, Germany

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October 1, 2024

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Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model

Journal of Nuclear Medicine Jul 2019, jnumed.119.227322; DOI: 10.2967/jnumed.119.227322

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Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model

Journal of Nuclear Medicine Jul 2019, jnumed.119.227322; DOI: 10.2967/jnumed.119.227322

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Keywords

Animal Imaging
neurology
PET
β-amyloid
Alzheimers Disease
AppNL-G-F
microglia
spatial learning

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