Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Corporate & Special Sales
    • Journal Claims
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Permissions
    • Advertisers
    • Continuing Education
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Corporate & Special Sales
    • Journal Claims
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Permissions
    • Advertisers
    • Continuing Education
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • Follow JNM on Twitter
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Subscribe to our RSS feeds
OtherBasic Science (Animal or Phantoms)

Early and longitudinal microglial activation but not amyloid accumulation predict cognitive outcome in PS2APP mice

Carola Focke, Tanja Blume, Benedikt Zott, Yuan Shi, Maximilian Deussing, Finn Peters, Claudio Schmidt, Gernot Kleinberger, Simon Lindner, Franz-Josef Gildehaus, Leonie Beyer, Barbara von Ungern-Sternberg, Peter Bartenstein, Laurence Ozmen, Karlheinz Baumann, Mario M Dorostkar, Christian Haass, Helmuth Adelsberger, Jochen Herms, Axel Rominger and Matthias Brendel
Journal of Nuclear Medicine October 2018, jnumed.118.217703; DOI: https://doi.org/10.2967/jnumed.118.217703
Carola Focke
1 Dept. of Nuclear Medicine, University Hospital of Munich, LMU Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tanja Blume
1 Dept. of Nuclear Medicine, University Hospital of Munich, LMU Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Benedikt Zott
2 Institute of Neuroscience, TU Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yuan Shi
3 Center for Neuropathology and Prion Research LMU Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maximilian Deussing
1 Dept. of Nuclear Medicine, University Hospital of Munich, LMU Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Finn Peters
4 DZNE - German Center for Neurodegenerative Diseases, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Claudio Schmidt
1 Dept. of Nuclear Medicine, University Hospital of Munich, LMU Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gernot Kleinberger
5 Biomedical Center (BMC) Biochemistry LMU Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Simon Lindner
1 Dept. of Nuclear Medicine, University Hospital of Munich, LMU Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Franz-Josef Gildehaus
1 Dept. of Nuclear Medicine, University Hospital of Munich, LMU Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leonie Beyer
1 Dept. of Nuclear Medicine, University Hospital of Munich, LMU Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Barbara von Ungern-Sternberg
1 Dept. of Nuclear Medicine, University Hospital of Munich, LMU Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter Bartenstein
1 Dept. of Nuclear Medicine, University Hospital of Munich, LMU Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laurence Ozmen
6 Roche Pharma Research and Early Development, F. Hoffmann-La Roche Ltd., Switzerland;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Karlheinz Baumann
6 Roche Pharma Research and Early Development, F. Hoffmann-La Roche Ltd., Switzerland;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mario M Dorostkar
7 Center for Neuropathology and Prion Research, Ludwig-Maximilians-University of Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christian Haass
4 DZNE - German Center for Neurodegenerative Diseases, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Helmuth Adelsberger
2 Institute of Neuroscience, TU Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jochen Herms
3 Center for Neuropathology and Prion Research LMU Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Axel Rominger
1 Dept. of Nuclear Medicine, University Hospital of Munich, LMU Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthias Brendel
1 Dept. of Nuclear Medicine, University Hospital of Munich, LMU Munich, Germany;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • PDF
Loading

Abstract

Neuroinflammation may have beneficial or detrimental net effects on the cognitive outcome of Alzheimer’s disease patients (AD). 18kDa translocator protein (TSPO) imaging by positron-emission-tomography (PET) enables longitudinal monitoring of microglial activation in vivo. We compiled serial PET measures of TSPO and amyloid with terminal cognitive assessment (water maze) in an AD transgenic mouse model (PS2APP) from eight to 13 months of age, followed by immunohistochemical analyses of microglia, amyloid and synaptic density. Better cognitive outcome and higher synaptic density in PS2APP mice was predicted by higher TSPO expression at eight months. The progression of TSPO activation to 13 months also showed a moderate association with spared cognition, but amyloidosis did not correlate with the cognitive outcome, regardless of the timepoint. This first PET investigation with longitudinal TSPO- and amyloid-PET together with terminal cognitive testing in an AD mouse model indicates that continuing microglial response seems to impart preserved cognitive performance.

  • Animal Imaging
  • Neurology
  • PET
  • Amyloid-PET
  • TSPO-PET
  • neuroinflammation
  • synaptic density
  • water maze
  • Copyright © 2018 by the Society of Nuclear Medicine and Molecular Imaging, Inc.
PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine: 64 (3)
Journal of Nuclear Medicine
Vol. 64, Issue 3
March 1, 2023
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Complete Issue (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Early and longitudinal microglial activation but not amyloid accumulation predict cognitive outcome in PS2APP mice
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
Early and longitudinal microglial activation but not amyloid accumulation predict cognitive outcome in PS2APP mice
Carola Focke, Tanja Blume, Benedikt Zott, Yuan Shi, Maximilian Deussing, Finn Peters, Claudio Schmidt, Gernot Kleinberger, Simon Lindner, Franz-Josef Gildehaus, Leonie Beyer, Barbara von Ungern-Sternberg, Peter Bartenstein, Laurence Ozmen, Karlheinz Baumann, Mario M Dorostkar, Christian Haass, Helmuth Adelsberger, Jochen Herms, Axel Rominger, Matthias Brendel
Journal of Nuclear Medicine Oct 2018, jnumed.118.217703; DOI: 10.2967/jnumed.118.217703

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Early and longitudinal microglial activation but not amyloid accumulation predict cognitive outcome in PS2APP mice
Carola Focke, Tanja Blume, Benedikt Zott, Yuan Shi, Maximilian Deussing, Finn Peters, Claudio Schmidt, Gernot Kleinberger, Simon Lindner, Franz-Josef Gildehaus, Leonie Beyer, Barbara von Ungern-Sternberg, Peter Bartenstein, Laurence Ozmen, Karlheinz Baumann, Mario M Dorostkar, Christian Haass, Helmuth Adelsberger, Jochen Herms, Axel Rominger, Matthias Brendel
Journal of Nuclear Medicine Oct 2018, jnumed.118.217703; DOI: 10.2967/jnumed.118.217703
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • PDF

Related Articles

  • This Month in JNM
  • PubMed
  • Google Scholar

Cited By...

  • The Future of Nuclear Medicine Depends on the Quality of Its Research: Researchers at the University of Heidelberg Receive the Award for Best Article of the Year
  • Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the A{beta}42:A{beta}40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model
  • Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second-Generation Amyloid-{beta} Mouse Model
  • Google Scholar

More in this TOC Section

Basic Science (Animal or Phantoms)

  • Site-Specifically Conjugated Single-Domain Antibody Successfully Identifies Glypican-3–Expressing Liver Cancer by Immuno-PET
  • Signaling Network Response to Alpha-Particle Targeted Therapy with Actinium-225 Labeled Minigastrin Analogue 225Ac-PP-F11N Reveals Radiosensitizing Potential of HDAC Inhibitors
  • Radiolabeled GPVI-Fc for PET imaging of multiple extracellular matrix fibers: A new look into pulmonary fibrosis progression.
Show more Basic Science (Animal or Phantoms)

Basic (Neurology)

  • 11C-PiB and 124I-Antibody PET Provide Differing Estimates of Brain Amyloid-β After Therapeutic Intervention
Show more Basic (Neurology)

Similar Articles

Keywords

  • Animal Imaging
  • Neurology
  • PET
  • Amyloid-PET
  • TSPO-PET
  • neuroinflammation
  • synaptic density
  • water maze
SNMMI

© 2023 Journal of Nuclear Medicine

Powered by HighWire