Abstract
Aim: To assess the impact of 68Ga-Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography/ Computed Tomography (PET/CT) on management of prostate cancer in patients with biochemical recurrence (BCR). Methods: Documented management plans were retrospectively reviewed before and after 68Ga-PSMA PET/CT in 100 patients with BCR and change in plans recorded. Results: Management changed after 68Ga-PSMA PET/CT in 39 patients (39%). These occurred in 23/68 (33.8%) of patients with radical prostatectomy (RP) and 16/32 (50%) of patients previously treated with radical radiotherapy. Positive scan (P < 0.001) and higher Prostate Specific Antigen (PSA) (P = 0.024) were associated with management changes. No significant association with management change was found with Gleason grade, stage, presence of metastatic disease, PSA velocity or doubling time. Conclusion: 68Ga-PSMA PET/CT altered management in 39% of patients with BCR, and occurred more often in patients with radical radiotherapy treatment, a positive 68Ga-PSMA scan and higher PSA level.
- Copyright © 2017 by the Society of Nuclear Medicine and Molecular Imaging, Inc.