Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • Log out
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • Log out
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Research ArticleClinical Investigation

Dynamic 18F-FET PET in Newly Diagnosed Astrocytic Low-Grade Glioma Identifies High-Risk Patients

Nathalie L. Jansen, Bogdana Suchorska, Vera Wenter, Sabina Eigenbrod, Christine Schmid-Tannwald, Andreas Zwergal, Maximilian Niyazi, Mark Drexler, Peter Bartenstein, Oliver Schnell, Jörg-Christian Tonn, Niklas Thon, Friedrich-Wilhelm Kreth and Christian la Fougère
Journal of Nuclear Medicine December 2013, jnumed.113.122333; DOI: https://doi.org/10.2967/jnumed.113.122333
Nathalie L. Jansen
1Department of Nuclear Medicine, University of Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bogdana Suchorska
2Department of Neurosurgery, University of Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vera Wenter
1Department of Nuclear Medicine, University of Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sabina Eigenbrod
3Department of Neuropathology, University of Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christine Schmid-Tannwald
4Institute for Clinical Radiology, University of Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andreas Zwergal
5Department of Neurology, University of Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maximilian Niyazi
6Department of Radiation Oncology, University of Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark Drexler
1Department of Nuclear Medicine, University of Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter Bartenstein
1Department of Nuclear Medicine, University of Munich, Munich, Germany
7Munich Cluster for Systems Neurology (SyNergy), University of Munich, Munich, Germany; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Oliver Schnell
2Department of Neurosurgery, University of Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jörg-Christian Tonn
2Department of Neurosurgery, University of Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Niklas Thon
2Department of Neurosurgery, University of Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Friedrich-Wilhelm Kreth
2Department of Neurosurgery, University of Munich, Munich, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christian la Fougère
1Department of Nuclear Medicine, University of Munich, Munich, Germany
7Munich Cluster for Systems Neurology (SyNergy), University of Munich, Munich, Germany; and
8Department of Clinical Molecular Imaging and Nuclear Medicine, University Hospital Tuebingen, Tuebingen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • PDF
Loading

Abstract

Because the clinical course of low-grade gliomas in the individual adult patient varies considerably and is unpredictable, we investigated the prognostic value of dynamic 18F-fluorethyltyrosine (18F-FET) PET in the early diagnosis of astrocytic low-grade glioma (World Health Organization grade II). Methods: Fifty-nine patients with newly diagnosed low-grade glioma and dynamic 18F-FET PET before histopathologic assessment were retrospectively investigated. 18F-FET PET analysis comprised a qualitative visual classification of lesions; assessment of the semiquantitative parameters maximal, mean, and total standardized uptake value as ratio to background and biologic tumor volume; and dynamic analysis of intratumoral 18F-FET uptake over time (increasing vs. decreasing time–activity curves). The correlation between PET parameters and progression-free survival, overall survival, and time to malignant transformation was investigated. Results: 18F-FET uptake greater than the background level was found in 34 of 59 tumors. Dynamic 18F-FET uptake analysis was available for 30 of these 34 patients. Increasing and decreasing time–activity curves were found in 18 and 12 patients, respectively. Neither the qualitative factor presence or absence of 18F-FET uptake nor any of the semiquantitative uptake parameters significantly influenced clinical outcome. In contrast, decreasing time–activity curves in the kinetic analysis were highly prognostic for shorter progression-free survival and time to malignant transformation (P < 0.001). Conclusion: Absence of 18F-FET uptake in newly diagnosed astrocytic low-grade glioma does not generally indicate an indolent disease course. Among the 18F-FET–positive gliomas, decreasing time–activity curves in dynamic 18F-FET PET constitute an unfavorable prognostic factor in astrocytic low-grade glioma and, by identifying high-risk patients, may ease treatment decisions.

  • low grade glioma
  • FET-PET
  • kinetic analysis
  • prognostic value

Footnotes

  • Published online ▪▪▪.

  • © 2014 by the Society of Nuclear Medicine and Molecular Imaging, Inc.
Next
Back to top

In this issue

Journal of Nuclear Medicine: 66 (6)
Journal of Nuclear Medicine
Vol. 66, Issue 6
June 1, 2025
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Complete Issue (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Dynamic 18F-FET PET in Newly Diagnosed Astrocytic Low-Grade Glioma Identifies High-Risk Patients
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
Dynamic 18F-FET PET in Newly Diagnosed Astrocytic Low-Grade Glioma Identifies High-Risk Patients
Nathalie L. Jansen, Bogdana Suchorska, Vera Wenter, Sabina Eigenbrod, Christine Schmid-Tannwald, Andreas Zwergal, Maximilian Niyazi, Mark Drexler, Peter Bartenstein, Oliver Schnell, Jörg-Christian Tonn, Niklas Thon, Friedrich-Wilhelm Kreth, Christian la Fougère
Journal of Nuclear Medicine Dec 2013, jnumed.113.122333; DOI: 10.2967/jnumed.113.122333

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Dynamic 18F-FET PET in Newly Diagnosed Astrocytic Low-Grade Glioma Identifies High-Risk Patients
Nathalie L. Jansen, Bogdana Suchorska, Vera Wenter, Sabina Eigenbrod, Christine Schmid-Tannwald, Andreas Zwergal, Maximilian Niyazi, Mark Drexler, Peter Bartenstein, Oliver Schnell, Jörg-Christian Tonn, Niklas Thon, Friedrich-Wilhelm Kreth, Christian la Fougère
Journal of Nuclear Medicine Dec 2013, jnumed.113.122333; DOI: 10.2967/jnumed.113.122333
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • PDF

Related Articles

  • This Month in JNM
  • PubMed
  • Google Scholar

Cited By...

  • Imaging Tumor Metabolism
  • Amino Acid Tracer PET MRI in Glioma Management: What a Neuroradiologist Needs to Know
  • 18F-FET PET Uptake Characteristics in Patients with Newly Diagnosed and Untreated Brain Metastasis
  • Serial 18F-FET PET Imaging of Primarily 18F-FET-Negative Glioma: Does It Make Sense?
  • Prognostic Significance of Dynamic 18F-FET PET in Newly Diagnosed Astrocytic High-Grade Glioma
  • Clinical Impact of Amino Acid PET in Gliomas
  • Google Scholar

More in this TOC Section

  • The Use of PSMA PET/CT Improves Overall Survival in Men with Biochemically Recurrent Prostate Cancer Treated with Salvage Radiotherapy: Real-World Data from an Entire Country
  • Evaluation of 134Ce/134La-PSMA-617 for PET Imaging and Auger Electron Therapy of Prostate Cancer
  • SNMMI Procedure Standard/EANM Practice Guideline for Brain [18F]FDG PET Imaging, Version 2.0
Show more Clinical Investigation

Similar Articles

Keywords

  • low grade glioma
  • FET-PET
  • kinetic analysis
  • prognostic value
SNMMI

© 2025 SNMMI

Powered by HighWire