Abstract
In asthma, the relationship among airway inflammation, airway hyperresponsiveness, and lung function is poorly understood. Methods to noninvasively assess these relationships in human subjects are needed. We sought to determine whether 18F-FDG uptake rate (Ki, min−1) could serve as a biomarker of eosinophilic inflammation and local lung function. Methods: We used PET/CT to assess regional pulmonary perfusion (
- airway constriction
- ventilation–perfusion ratio
- pulmonary gas exchange
- fluorine isotopes
- emission-computed tomography
- nitrogen isotopes
Footnotes
Published online ■■■■.
- © 2011 by Society of Nuclear Medicine