Human Epidermal Growth Factor Receptor 2 (HER2) PET Imaging of HER2-Low Breast Cancer with [68Ga]Ga-ABY-025: Results from a Pilot Study

Renske Altena; Siri af Burén; August Blomgren; Emelie Karlsson; Antonios Tzortzakakis; Nikolai Brun; Mohammad M. Moein; Emma Jussing; Fredrik Y. Frejd; Jonas Bergh; Thuy A. Tran; Johan Hartman; Rimma Axelsson

doi:10.2967/jnumed.123.266847

Research ArticleClinical Investigation

Human Epidermal Growth Factor Receptor 2 (HER2) PET Imaging of HER2-Low Breast Cancer with [⁶⁸Ga]Ga-ABY-025: Results from a Pilot Study

Renske Altena, Siri af Burén, August Blomgren, Emelie Karlsson, Antonios Tzortzakakis, Nikolai Brun, Mohammad M. Moein, Emma Jussing, Fredrik Y. Frejd, Jonas Bergh, Thuy A. Tran, Johan Hartman and Rimma Axelsson

Journal of Nuclear Medicine May 2024, 65 (5) 700-707; DOI: https://doi.org/10.2967/jnumed.123.266847

Renske Altena

1Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Solna, Sweden;

2Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden;

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Siri af Burén

3Division of Radiology, Department for Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden;

4Medical Radiation Physics and Nuclear Medicine, Functional Unit of Nuclear Medicine, Karolinska University Hospital, Huddinge, Sweden;

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August Blomgren

4Medical Radiation Physics and Nuclear Medicine, Functional Unit of Nuclear Medicine, Karolinska University Hospital, Huddinge, Sweden;

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Emelie Karlsson

2Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden;

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Antonios Tzortzakakis

3Division of Radiology, Department for Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden;

4Medical Radiation Physics and Nuclear Medicine, Functional Unit of Nuclear Medicine, Karolinska University Hospital, Huddinge, Sweden;

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Nikolai Brun

5Affibody AB, Solna, Sweden;

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Mohammad M. Moein

6Department of Radiopharmacy, Karolinska University Hospital, Solna, Sweden;

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Emma Jussing

2Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden;

6Department of Radiopharmacy, Karolinska University Hospital, Solna, Sweden;

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Fredrik Y. Frejd

5Affibody AB, Solna, Sweden;

7Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden;

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Jonas Bergh

1Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Solna, Sweden;

2Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden;

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Thuy A. Tran

2Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden;

6Department of Radiopharmacy, Karolinska University Hospital, Solna, Sweden;

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Johan Hartman

2Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden;

8Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Solna, Sweden; and

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Rimma Axelsson

4Medical Radiation Physics and Nuclear Medicine, Functional Unit of Nuclear Medicine, Karolinska University Hospital, Huddinge, Sweden;

9Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

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Journal of Nuclear Medicine

Vol. 65, Issue 5

May 1, 2024

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Human Epidermal Growth Factor Receptor 2 (HER2) PET Imaging of HER2-Low Breast Cancer with [⁶⁸Ga]Ga-ABY-025: Results from a Pilot Study

Journal of Nuclear Medicine May 2024, 65 (5) 700-707; DOI: 10.2967/jnumed.123.266847

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Human Epidermal Growth Factor Receptor 2 (HER2) PET Imaging of HER2-Low Breast Cancer with [⁶⁸Ga]Ga-ABY-025: Results from a Pilot Study

Journal of Nuclear Medicine May 2024, 65 (5) 700-707; DOI: 10.2967/jnumed.123.266847

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Keywords

HER2 PET
HER2-low breast cancer
[68Ga]Ga-ABY-025

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