Biodistribution, Dosimetry, and Pharmacokinetics of 68Ga-CBP8: A Type I Collagen–Targeted PET Probe

David Izquierdo-Garcia; Pauline Désogère; Mariane Le Fur; Sergey Shuvaev; Iris Y. Zhou; Ian Ramsay; Michael Lanuti; Onofrio A. Catalano; Ciprian Catana; Peter Caravan; Sydney B. Montesi

doi:10.2967/jnumed.122.264530

Research ArticleClinical Investigations

Biodistribution, Dosimetry, and Pharmacokinetics of ⁶⁸Ga-CBP8: A Type I Collagen–Targeted PET Probe

David Izquierdo-Garcia, Pauline Désogère, Mariane Le Fur, Sergey Shuvaev, Iris Y. Zhou, Ian Ramsay, Michael Lanuti, Onofrio A. Catalano, Ciprian Catana, Peter Caravan and Sydney B. Montesi

Journal of Nuclear Medicine May 2023, 64 (5) 775-781; DOI: https://doi.org/10.2967/jnumed.122.264530

David Izquierdo-Garcia

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts;

2Harvard Medical School, Boston, Massachusetts;

3Harvard–MIT Division of Health Sciences and Technology, Cambridge, Massachusetts;

4Bioengineering Department, Universidad Carlos III de Madrid, Spain;

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Pauline Désogère

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts;

5Institute for Innovation in Imaging, Massachusetts General Hospital, Boston, Massachusetts;

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Mariane Le Fur

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts;

2Harvard Medical School, Boston, Massachusetts;

5Institute for Innovation in Imaging, Massachusetts General Hospital, Boston, Massachusetts;

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Sergey Shuvaev

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts;

2Harvard Medical School, Boston, Massachusetts;

5Institute for Innovation in Imaging, Massachusetts General Hospital, Boston, Massachusetts;

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Iris Y. Zhou

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts;

2Harvard Medical School, Boston, Massachusetts;

5Institute for Innovation in Imaging, Massachusetts General Hospital, Boston, Massachusetts;

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Ian Ramsay

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts;

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Michael Lanuti

2Harvard Medical School, Boston, Massachusetts;

6Division of Thoracic Surgery, Massachusetts General Hospital, Boston, Massachusetts; and

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Onofrio A. Catalano

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts;

2Harvard Medical School, Boston, Massachusetts;

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Ciprian Catana

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts;

2Harvard Medical School, Boston, Massachusetts;

5Institute for Innovation in Imaging, Massachusetts General Hospital, Boston, Massachusetts;

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Peter Caravan

1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts;

2Harvard Medical School, Boston, Massachusetts;

5Institute for Innovation in Imaging, Massachusetts General Hospital, Boston, Massachusetts;

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Sydney B. Montesi

2Harvard Medical School, Boston, Massachusetts;

5Institute for Innovation in Imaging, Massachusetts General Hospital, Boston, Massachusetts;

7Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts

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Vol. 64, Issue 5

May 1, 2023

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Biodistribution, Dosimetry, and Pharmacokinetics of ⁶⁸Ga-CBP8: A Type I Collagen–Targeted PET Probe

David Izquierdo-Garcia, Pauline Désogère, Mariane Le Fur, Sergey Shuvaev, Iris Y. Zhou, Ian Ramsay, Michael Lanuti, Onofrio A. Catalano, Ciprian Catana, Peter Caravan, Sydney B. Montesi

Journal of Nuclear Medicine May 2023, 64 (5) 775-781; DOI: 10.2967/jnumed.122.264530

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Biodistribution, Dosimetry, and Pharmacokinetics of ⁶⁸Ga-CBP8: A Type I Collagen–Targeted PET Probe

David Izquierdo-Garcia, Pauline Désogère, Mariane Le Fur, Sergey Shuvaev, Iris Y. Zhou, Ian Ramsay, Michael Lanuti, Onofrio A. Catalano, Ciprian Catana, Peter Caravan, Sydney B. Montesi

Journal of Nuclear Medicine May 2023, 64 (5) 775-781; DOI: 10.2967/jnumed.122.264530

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Keywords

68Ga-CBP8
PET
fibrosis
collagen
dosimetry

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Biodistribution, Dosimetry, and Pharmacokinetics of ⁶⁸Ga-CBP8: A Type I Collagen–Targeted PET Probe

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