2022 highlights in oncology and therapy: Schöder reviews recent noteworthy studies in clinical radionuclide therapy and experimental science in the second of a 2-part series from the SNMMI Annual Meeting.
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Discussions with leaders: Bodei and Czernin talk with Ken Song, president and CEO of RayzeBio, about his career as a physician, venture capitalist, industry CEO, and global research and commercialization leader.
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CNS drug development: Seibyl provides a state-of-the-art look at imaging biomarkers for central nervous system drug development and the ways in which these have evolved and will inform future nuclear medicine practice in neurodegenerative disorders.
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Brain trauma imaging: Bischof and Cross detail challenges posed by mechanistic understanding of chronic traumatic brain injury when interpreting molecular biomarker imaging and call for better target identification, improved analytic techniques, and novel tracer development.
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Imaging activated T cells: Sako and Larimer offer an overview of recent advances in T-cell activation imaging and describe future directions for potential clinical nuclear medicine applications in immunotherapy.
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CXCR4-directed theranostics in TCL: Buck and colleagues report on results in patients with advanced T-cell lymphoma who underwent 68Ga-pentixafor PET/CT for C-X-C motif chemokine receptor 4–targeted therapy as a conditioning regimen, followed by hematopoietic stem cell transplantation.
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Efficacy of submaximal dosage of PRRT: Minczeles and colleagues analyze outcomes with submaximal activities of 177Lu-DOTATATE peptide-receptor radionuclide therapy in patients with neuroendocrine tumors who had discontinued treatment for non–disease-related reasons.
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PCa theranostic survey: Beyer and colleagues detail the results of a web-based survey of global experience with and expectations of prostate-specific membrane antigen imaging using [68Ga]- or [18F]-labeled ligands and PSMA-based radioligand therapy for prostate cancer.
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Extended 177Lu-PSMA treatment: Derlin and colleagues evaluate the feasibility, additional benefit, and toxicity of extending prostate-specific membrane antigen–targeted radioligand therapy in patients with metastatic castration-resistant prostate cancer.
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99mTc-MIP-1404 in RGS of recurrent PCa: Koehler and colleagues explore the feasibility of prostate-specific membrane antigen–radioguided surgery with 99mTc-MIP-1404, a small-molecule PSMA inhibitor, in recurrent prostate cancer.
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PSMA saturation after 68Ga-PSMA-11: Siebinga and colleagues investigate the potential effects on 68Ga–prostate-specific membrane antigen–11 tumor uptake in PET/CT when varying the administered peptide amount in patients with primary prostate cancer.
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Imaging after 177Lu-PSMA-617: Pathmanandavel and colleagues research the prognostic value of posttreatment quantitative PET assessment of prostate-specific antigen for progression-free and overall survival after 177Lu-PSMA-617 therapy.
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PET/CT in NSCLC and subsequent radiation: Sterbis and colleagues evaluate the use of 18F-FDG PET/CT imaging before radiation therapy in patients with non–small cell lung cancer as recommended by national guidelines, including corresponding results in cancer-specific survival.
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Fluorescence imaging of the pancreas: Mulder and colleagues report on the feasibility and safety of intraoperative tumor-specific imaging of pancreatic cancer with the near-infrared fluorescent tracer bevacizumab-800CW.
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Sestamibi SPECT/CT for renal masses: Parihar and colleagues assess the diagnostic accuracy of 99mTc-sestamibi SPECT/CT for characterizing solid renal masses, specifically for differentiating malignant or aggressive renal tumors from benign or indolent lesions.
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Whole-body PET/MRI in pediatric HL: Georgi and colleagues identify the optimal whole-body MRI sequence for pretreatment PET/MRI in Hodgkin lymphoma, with the intention of optimizing workflow and reducing imaging acquisition time.
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PRoLoG initiative on Lugano classification: Ricard and colleagues present the first in a 2-part series on consensus recommendations from academic and industry experts in lymphoma and imaging for consistent application of the Lugano lymphoma classification system.
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213Bi-anti-CD20 for lymphoma in mice: Havlena and colleagues explore the feasibility of using α-emitting 213Bi-anti-CD20 therapy with direct bioluminescent tracking of micrometastatic human B-cell lymphoma in a mouse model of non-Hodgkin lymphoma.
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PET and systemic STING: Le and colleagues investigate whether activation of the systemic stimulator of interferon genes (a mediator of immune recognition of cytosolic DNA) induces metabolic alterations in immune cells that can be visualized by 18F-FDG PET.
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211At-labeled anti-HER2 sdAb TAT: Feng and colleagues assess the therapeutic potential of targeted α-particle therapy with single-domain antibody fragments that bind with high affinity to domain IV of human epidermal growth factor receptor type 2.
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18F-Fluciclovine as a marker of GLSi: Zhou and colleagues assess 18F-fluciclovine as a PET imaging biomarker for detecting the pharmacodynamic response to a novel glutaminase inhibitor, GLSi, in human breast cancer cells.
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Antigen-inducible PET reporter system: Shin and colleagues detail engineering of a synthetic intramembrane proteolysis receptor PET reporter and its application to high-sensitivity cell-based antigen detection as well as mapping of engineered T-cell–antigen interactions in vivo.
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Neutrophil elastase in COVID-19: Antoni and colleagues describe 11C-NES, a novel PET tracer for neutrophil elastase, and evaluate it in a first-in-humans study in hypoxia related to COVID-19.
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Credentialing statement for cardiac PET/MRI: Ruddy and colleagues from a joint professional task force provide a consensus statement intended to guide credentialing bodies that privilege physicians to oversee, supervise, and interpret cardiac PET/MRI for U.S. patient care.
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Dedicated head PET: Ishii and colleagues assess 18F-FDG and 18F-flutemetamol brain PET images using both a time-of-flight system dedicated to the head and a conventional whole-body PET/CT system and compare results.
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PET imaging of COX-1: Kim and colleagues analyze the selectivity of 11C-PS13 binding to cyclooxygenase-1 in humans and assess the utility of 11C-PS13 to measure the in vivo potency of nonsteroidal antiinflammatory drugs.
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Excess cancer after 211At TAT: Leidermark and colleagues provide data and insights on estimated relative risk of secondary cancer after 211At-monoclonal antibody–based intraperitoneal targeted α therapy.
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Experimental 212Pb generator: Li and colleagues describe the development, performance, and radiation safety of an experimental generator for production of 212Pb intended for radiopharmaceuticals.
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Shortwave-infrared CLI: Mc Larney and colleagues report on studies showing that radioisotope shortwave-infrared Cerenkov luminescence imaging can be performed with unmodified commercially available components, offering advantages over visible-wavelength CLI.
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- © 2023 by the Society of Nuclear Medicine and Molecular Imaging.