Research ArticleFeatured Basic Science Article
Combination of Carriers with Complementary Intratumoral Microdistributions of Delivered α-Particles May Realize the Promise for 225Ac in Large, Solid Tumors
Alaina Howe, Omkar Bhatavdekar, Dominick Salerno, Anders Josefsson, Jesus Pacheco-Torres, Zaver M. Bhujwalla, Kathleen L. Gabrielson, George Sgouros and Stavroula Sofou
Journal of Nuclear Medicine August 2022, 63 (8) 1223-1230; DOI: https://doi.org/10.2967/jnumed.121.262992
Alaina Howe
1Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland;
Omkar Bhatavdekar
1Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland;
Dominick Salerno
1Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland;
Anders Josefsson
2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland;
Jesus Pacheco-Torres
2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland;
Zaver M. Bhujwalla
2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland;
Kathleen L. Gabrielson
3Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, Maryland; and
George Sgouros
2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland;
Stavroula Sofou
1Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland;
4Sidney Kimmel Comprehensive Cancer Center, Cancer Invasion and Metastasis Program, Department of Oncology, Johns Hopkins University, Baltimore, Maryland

Data supplements
Supplemental Data
Files in this Data Supplement:
In this issue
Journal of Nuclear Medicine
Vol. 63, Issue 8
August 1, 2022
Combination of Carriers with Complementary Intratumoral Microdistributions of Delivered α-Particles May Realize the Promise for 225Ac in Large, Solid Tumors
Alaina Howe, Omkar Bhatavdekar, Dominick Salerno, Anders Josefsson, Jesus Pacheco-Torres, Zaver M. Bhujwalla, Kathleen L. Gabrielson, George Sgouros, Stavroula Sofou
Journal of Nuclear Medicine Aug 2022, 63 (8) 1223-1230; DOI: 10.2967/jnumed.121.262992
Combination of Carriers with Complementary Intratumoral Microdistributions of Delivered α-Particles May Realize the Promise for 225Ac in Large, Solid Tumors
Alaina Howe, Omkar Bhatavdekar, Dominick Salerno, Anders Josefsson, Jesus Pacheco-Torres, Zaver M. Bhujwalla, Kathleen L. Gabrielson, George Sgouros, Stavroula Sofou
Journal of Nuclear Medicine Aug 2022, 63 (8) 1223-1230; DOI: 10.2967/jnumed.121.262992
Jump to section
Related Articles
Cited By...
- MIRD Pamphlet No. 31: MIRDcell V4--Artificial Intelligence Tools to Formulate Optimized Radiopharmaceutical Cocktails for Therapy
- Glioblastoma Treatment by Systemic Actinium-225 {alpha}-particle Dendrimer-radioconjugates is Improved by Chemotherapy
- Transport Cocktails for Cancer Therapeutics
- Tumor Control Probability and Small-Scale Monte Carlo Dosimetry: Effects of Heterogenous Intratumoral Activity Distribution in Radiopharmaceutical Therapy
- Combined, yet Separate: cocktails of carriers (not drugs) for {alpha}-particle therapy of solid tumors expressing moderate-to-low levels of targetable markers