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Research ArticleHot Topics

Tau Beats Amyloid in Predicting Brain Atrophy in Alzheimer Disease: Implications for Prognosis and Clinical Trials

Maura Malpetti, Renaud La Joie and Gil D. Rabinovici
Journal of Nuclear Medicine June 2022, 63 (6) 830-832; DOI: https://doi.org/10.2967/jnumed.121.263694
Maura Malpetti
1Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California;
2Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom; and
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Renaud La Joie
1Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California;
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Gil D. Rabinovici
1Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California;
3Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California
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    FIGURE 1.

    Single-subject amyloid and tau PET patterns at baseline and cortical atrophy over time. (Left and middle) 11C-Pittsburgh compound B (PIB) and 18F-flortaucipir (FTP) PET SUV ratio maps, respectively, with higher values indicate more severe pathology. (Right) Patterns derived from prospective longitudinal structural MRI scans after PET, with positive Jacobians indicating shrinkage over time. Patient 1 is 71-y-old with mild AD dementia; patient 2 is 61-y-old with mild AD dementia.

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Journal of Nuclear Medicine: 63 (6)
Journal of Nuclear Medicine
Vol. 63, Issue 6
June 1, 2022
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Tau Beats Amyloid in Predicting Brain Atrophy in Alzheimer Disease: Implications for Prognosis and Clinical Trials
Maura Malpetti, Renaud La Joie, Gil D. Rabinovici
Journal of Nuclear Medicine Jun 2022, 63 (6) 830-832; DOI: 10.2967/jnumed.121.263694

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Tau Beats Amyloid in Predicting Brain Atrophy in Alzheimer Disease: Implications for Prognosis and Clinical Trials
Maura Malpetti, Renaud La Joie, Gil D. Rabinovici
Journal of Nuclear Medicine Jun 2022, 63 (6) 830-832; DOI: 10.2967/jnumed.121.263694
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