Research ArticleBasic Science Investigation
Influence of Fc Modifications and IgG Subclass on Biodistribution of Humanized Antibodies Targeting L1CAM
Sai Kiran Sharma, Maya Suzuki, Hong Xu, Joshua A. Korsen, Zachary Samuels, Hongfen Guo, Brandon Nemieboka, Alessandra Piersigilli, Kimberly J. Edwards, Nai-Kong V. Cheung and Jason S. Lewis
Journal of Nuclear Medicine April 2022, 63 (4) 629-636; DOI: https://doi.org/10.2967/jnumed.121.262383
Sai Kiran Sharma
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;
Maya Suzuki
2Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York;
3Center for Clinical and Translational Research, Kyushu University Hospital, Fukuoka, Japan;
Hong Xu
2Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York;
4Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York;
Joshua A. Korsen
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;
5Department of Pharmacology, Weill Cornell Medical College, New York, New York;
Zachary Samuels
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;
Hongfen Guo
2Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York;
4Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York;
Brandon Nemieboka
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;
6Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York;
Alessandra Piersigilli
7Tri-Institutional Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, and Rockefeller University, New York, New York;
Kimberly J. Edwards
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;
Nai-Kong V. Cheung
2Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York;
5Department of Pharmacology, Weill Cornell Medical College, New York, New York;
6Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York;
Jason S. Lewis
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York;
4Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York;
6Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York;
8Department of Radiology, Weill Cornell Medical College, New York, New York; and
9Radiochemistry and Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, New York
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Journal of Nuclear Medicine
Vol. 63, Issue 4
April 1, 2022
Influence of Fc Modifications and IgG Subclass on Biodistribution of Humanized Antibodies Targeting L1CAM
Sai Kiran Sharma, Maya Suzuki, Hong Xu, Joshua A. Korsen, Zachary Samuels, Hongfen Guo, Brandon Nemieboka, Alessandra Piersigilli, Kimberly J. Edwards, Nai-Kong V. Cheung, Jason S. Lewis
Journal of Nuclear Medicine Apr 2022, 63 (4) 629-636; DOI: 10.2967/jnumed.121.262383
Influence of Fc Modifications and IgG Subclass on Biodistribution of Humanized Antibodies Targeting L1CAM
Sai Kiran Sharma, Maya Suzuki, Hong Xu, Joshua A. Korsen, Zachary Samuels, Hongfen Guo, Brandon Nemieboka, Alessandra Piersigilli, Kimberly J. Edwards, Nai-Kong V. Cheung, Jason S. Lewis
Journal of Nuclear Medicine Apr 2022, 63 (4) 629-636; DOI: 10.2967/jnumed.121.262383