A Longitudinal PET/MRI Study of Colony-Stimulating Factor 1 Receptor–Mediated Microglia Depletion in Experimental Stroke

Cristina Barca; Amanda J. Kiliaan; Claudia Foray; Lydia Wachsmuth; Sven Hermann; Cornelius Faber; Michael Schäfers; Maximilian Wiesmann; Andreas H. Jacobs; Bastian Zinnhardt

doi:10.2967/jnumed.121.262279

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A Longitudinal PET/MRI Study of Colony-Stimulating Factor 1 Receptor–Mediated Microglia Depletion in Experimental Stroke

Cristina Barca, Amanda J. Kiliaan, Claudia Foray, Lydia Wachsmuth, Sven Hermann, Cornelius Faber, Michael Schäfers, Maximilian Wiesmann, Andreas H. Jacobs and Bastian Zinnhardt

Journal of Nuclear Medicine March 2022, 63 (3) 446-452; DOI: https://doi.org/10.2967/jnumed.121.262279

Cristina Barca

1European Institute for Molecular Imaging, University of Münster, Münster, Germany;

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Amanda J. Kiliaan

2Department of Medical Imaging/Anatomy, Radboud University Medical Center, Radboud, The Netherlands;

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Claudia Foray

1European Institute for Molecular Imaging, University of Münster, Münster, Germany;

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Lydia Wachsmuth

3Clinic of Radiology, Translational Research Imaging Center, University Hospital Münster, Münster, Germany;

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Sven Hermann

1European Institute for Molecular Imaging, University of Münster, Münster, Germany;

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Cornelius Faber

3Clinic of Radiology, Translational Research Imaging Center, University Hospital Münster, Münster, Germany;

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Michael Schäfers

1European Institute for Molecular Imaging, University of Münster, Münster, Germany;

4Department of Nuclear Medicine, University Hospital Münster, Münster, Germany;

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Maximilian Wiesmann

2Department of Medical Imaging/Anatomy, Radboud University Medical Center, Radboud, The Netherlands;

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Andreas H. Jacobs

1European Institute for Molecular Imaging, University of Münster, Münster, Germany;

5Department of Geriatrics and Neurology, Johanniter Hospital, Bonn, Germany; and

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Bastian Zinnhardt

1European Institute for Molecular Imaging, University of Münster, Münster, Germany;

4Department of Nuclear Medicine, University Hospital Münster, Münster, Germany;

6Biomarkers and Translational Technologies, Pharma Research and Early Development, F. Hoffmann-La Roche Ltd., Basel, Switzerland

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Journal of Nuclear Medicine

Vol. 63, Issue 3

March 1, 2022

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A Longitudinal PET/MRI Study of Colony-Stimulating Factor 1 Receptor–Mediated Microglia Depletion in Experimental Stroke

Cristina Barca, Amanda J. Kiliaan, Claudia Foray, Lydia Wachsmuth, Sven Hermann, Cornelius Faber, Michael Schäfers, Maximilian Wiesmann, Andreas H. Jacobs, Bastian Zinnhardt

Journal of Nuclear Medicine Mar 2022, 63 (3) 446-452; DOI: 10.2967/jnumed.121.262279

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A Longitudinal PET/MRI Study of Colony-Stimulating Factor 1 Receptor–Mediated Microglia Depletion in Experimental Stroke

Cristina Barca, Amanda J. Kiliaan, Claudia Foray, Lydia Wachsmuth, Sven Hermann, Cornelius Faber, Michael Schäfers, Maximilian Wiesmann, Andreas H. Jacobs, Bastian Zinnhardt

Journal of Nuclear Medicine Mar 2022, 63 (3) 446-452; DOI: 10.2967/jnumed.121.262279

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Short-Term Colony-Stimulating Factor 1 Receptor Inhibition-Induced Repopulation After Stroke Assessed by Longitudinal 18F-DPA-714 PET Imaging

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Keywords

colony stimulating factor-1 receptor
microglia
stroke
18F-DPA-714
MRI

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