Discussions with leaders: Marcelo Di Carli, MD, talks with Valentín Fuster, MD, PhD, whose long career as an international leader and innovator in cardiology has extended into large-scale collaborations to improve public health.
Page 1617
Intraoperative molecular imaging: Azari and colleagues provide a state-of-the-art overview of the history, mechanism, current oncologic applications, and future directions of intraoperative molecular imaging–guided optical biopsy.
Page 1620
Oligometastatic prostate cancer: Jadvar and colleagues review the current status and challenges associated with increasing recognition of distinct imaging techniques and metastasis-directed therapies for oligometastatic prostate disease.
Page 1628
Progress in combined TRT and ICI: Bellavia and colleagues focus on basic targeted radiopharmaceutical therapy radiobiology and survey emerging and clinically translated agents that have been combined with immune checkpoint inhibitors.
Page 1636
FDA and Locametz and Pluvicto approval: Hofling and colleagues offer commentary on FDA approval of this theranostic drug pair targeting PSMA and the successful codevelopment process that can serve as a model for future prostate cancer theranostic agents.
Page 1642
68Ga-PSMA PET/CT patterns: Emmett and colleagues report on a post hoc analysis of the PRIMARY study, proposing a 5-point score to optimize the accuracy of 68Ga-PSMA PET/CT for clinically significant prostate cancer in a low-prevalence population.
Page 1644
RECIP criteria: Gafita and colleagues describe development of a novel framework for response evaluation criteria in PSMA PET/CT (RECIP) and a composite classification combining responses by prostate-specific antigen measurements and by the RECIP criteria.
Page 1651
DETECT trial: Gondoputro and colleagues evaluate the safety and feasibility of 99mTc-based PSMA robot-assisted–radioguided surgery to improve intraoperative detection of lymph node metastases during primary radical prostatectomy for prostate cancer.
Page 1659
Automated pipeline for voxel dosimetry: Dewaraja and colleagues construct and test an integrated voxel-level pipeline that automates key components of the radiopharmaceutical dosimetry process and apply it in patient-specific dosimetry in 177Lu-DOTATATE therapy.
Page 1665
Post–COVID-19 vaccination and PSMA PET/CT: Notohamiprodjo and colleagues use 18F-rhPSMA PET/CT to document the prevalence, temporal response to vaccination, and characteristics of COVID-19 vaccine–associated lymphadenopathy.
Page 1673
Cost effectiveness of 18F-FET PET in glioma: Rosen and colleagues report on the overall effectiveness and cost effectiveness of serial 18F-FET PET compared with conventional MRI for early identification of responders to adjuvant temozolomide chemotherapy.
Page 1677
Feasibility of dual-tracer imaging: Roth and colleagues explore dual-tracer [18F]-FDG/[68Ga]Ga-FAPI-46 PET/CT imaging within a single session in patients with oropharyngeal or esophageal cancer and highlight the potential advantages of this approach.
Page 1683
68Ga-Pentixafor PET/CT performance: Buck and colleagues assess 68Ga-Pentixafor uptake and image contrast on PET/CT in a large variety of neoplasms to identify the most relevant clinical applications for C-X-C motif chemokine receptor 4–directed imaging.
Page 1687
Factors affecting molecular imaging: Zhou and colleagues compare clinical imaging performance using a fluorescent antibody in 3 cancer types to elucidate physical and biologic factors contributing to differential outcomes in macroscopic fluorescence imaging in tumors.
Page 1693
CD133-targeted immunoPET in SCLC: Kunihiro and colleagues target the neuroendocrine tumor neoantigen CD133 via antibody-based early detection and immunoPET to facilitate earlier and more accurate diagnosis of small cell lung cancer.
Page 1701
MHC-II PET imaging for immunotherapy: Yang and colleagues investigate the potential of tumor-specific major histocompatibility complex II protein expression in melanoma under treatment with interferon γ as a novel immuno-PET target to predict response to immunotherapy.
Page 1708
PET and targeted 227Th therapy: Broer and colleagues evaluate tumor uptake, biodistribution, and antitumor activity in preclinical PET imaging with 89Zr-mesothelin and 227Th-mesothelin and comment on the potential of theranostic applications with this antibody–chelator conjugate pair.
Page 1715
Hot spot imaging in CVD: Sperry and colleagues from the SNMMI, ASNC, and EANM describe the performance, interpretation, and reporting of hot spot imaging in nuclear cardiology, focusing on image acquisition and processing, methods of quantification, indications, and reporting.
Page 1722
DMI indices for parkinsonism: Wu and colleagues detail development of metabolic imaging indices based on deep learning to support differential diagnoses of early idiopathic Parkinson disease and atypical parkinsonian syndromes.
Page 1741
OI method for early tau PET detection: Lee and colleagues propose an overlap index method for detecting spatially identical, voxelwise SUV ratio elevations in sequential tau PET scans for early detection of tau binding.
Page 1748
18F-PI-2620 tau PET in PSP: Messerschmidt and colleagues investigate whether 18F-PI-2620 tau PET has the potential to improve imaging diagnosis of progressive supranuclear palsy as an adjunct to MRI.
Page 1754
[18F]FKTP-Me PET imaging of COX-1: Shukuri and colleagues report on the design of a fluorine-substituted benzoyl group of ketoprofen and its potential application in PET “proradiotracers” for in vivo PET study of cyclooxygenase-1.
Page 1761
Explainable AI and MPI accuracy: Miller and colleagues explore whether access to explainable deep learning prediction improves accuracy in physician interpretation of myocardial perfusion imaging.
Page 1768
CS1P1 dosimetry: Brier and colleagues evaluate in humans the safety, dosimetry, and characteristics of 11C-CS1P1, a radiotracer targeting sphingosine-1-phosphate receptor 1, which has a role in multiple sclerosis.
Page 1775
- © 2022 by the Society of Nuclear Medicine and Molecular Imaging.
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