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Meeting ReportPoster - PhysicianPharm

Evaluating the role of partial-volume correction in predicting survival in head and neck cancer

Mahdi Zirakchian Zadeh, Shadi Asadollahi, Fatemeh Kaghazchi, Siavash Mehdizadeh Seraj, William Raynor, Thomas Werner, Mona-Elisabeth Revheim, Jonathon Korostoff, Samuel Swisher-McClure and Abass Alavi
Journal of Nuclear Medicine May 2021, 62 (supplement 1) 1091;
Mahdi Zirakchian Zadeh
1Dental School of Medicine University of Pennsylvania Philadelphia PA United States
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Shadi Asadollahi
2Department of Radiology University of Pennsylvania Philadelphia PA United States
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Fatemeh Kaghazchi
2Department of Radiology University of Pennsylvania Philadelphia PA United States
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Siavash Mehdizadeh Seraj
3Department of Radiology Yale University New Haven CT United States
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William Raynor
2Department of Radiology University of Pennsylvania Philadelphia PA United States
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Thomas Werner
2Department of Radiology University of Pennsylvania Philadelphia PA United States
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Mona-Elisabeth Revheim
4Oslo University Hospital Oslo Norway
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Jonathon Korostoff
1Dental School of Medicine University of Pennsylvania Philadelphia PA United States
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Samuel Swisher-McClure
5Department of Radiation Oncology University of Pennsylvania Philadelphia PA United States
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Abass Alavi
2Department of Radiology University of Pennsylvania Philadelphia PA United States
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Abstract

1091

Background: Semi-quantitative analysis of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) can be hampered by the partial volume effect (PVE), especially for small sized lesions. The role of PVE in the assessment of head and neck cancer (HNC) survival has not been investigated in any previous study.

Purpose: To examine if applying partial volume correction (PVC) can improve the accuracy of 18F-FDG-PET/CT in predicting the survival of HNC patients.

Methods: The pre-treatment 18F-FDG-PET/CT of fifty-four HNC patients with squamous cell carcinoma (47 males, 7 females, median aged 59.5 years, range: 37.2-78.6) were retrospectively assessed. All of patients received linear accelerator (LINAC) for radiation therapy in their course of treatment. A blinded observer performed image analysis of the PET data. Using ROVER software, an adaptive contrast-oriented thresholding algorithm was used to segment lesions on the FDG-PET images. PVC was applied to the PET metrics (ROVER, ABX GmbH, Radeberg, Germany). SUVmean, total lesion glycolysis (TLG), partial volume-corrected SUVmean (pvcSUVmean) and pvcTLG were calculated. Receiver operating characteristic (ROC) was used to determine the area under curve (AUC). Univariate Cox regression analysis was performed to identify the factors associated with progression-free survival (PFS). PFS was defined from the date of start of treatment until disease progression or death.

Results: Applying PVC was associated with a significant increase in the PET metrics (from 7.9± 4.4 to 11.9± 6.9 for SUVmean and from 182.9 ± 157.6 to 264.8 ± 219.5 for TLG; p< .001). AUCs were .425 (95% CI: .266-.585) for SUVmean and .415 (.257-.574) for pvcSUVmean. Moreover, AUC was .592 (.432-.752) for the volumetric PET metric, TLG, before applying PVC and was .590 (.431-.749) after applying PVC. In a univariate Cox regression analysis, both TLG and pvcTLG were prognostic factors for PFS (HR: 1.002, 95% CI: 1-1.005; p= .04 and HR: 1.002, 95% CI: 1-1.004; p= .03, respectively). The results for SUVmean and pvcSUVmean were not significant (p> .05).

Conclusions: This is the first study that assessed the prognostic significance of PVC in head and neck cancers. Although we did not observer a significant improvement for predicting PFS after applying partial volume correction to PET metrics, pvcTLG showed to be a reliable prognostic factor for evaluation of survival in the patients. We further suggest conducting more studies assessing small lesions (less than 1 centimeter), since these lesions are the most susceptible to PVE.

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Journal of Nuclear Medicine
Vol. 62, Issue supplement 1
May 1, 2021
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Evaluating the role of partial-volume correction in predicting survival in head and neck cancer
Mahdi Zirakchian Zadeh, Shadi Asadollahi, Fatemeh Kaghazchi, Siavash Mehdizadeh Seraj, William Raynor, Thomas Werner, Mona-Elisabeth Revheim, Jonathon Korostoff, Samuel Swisher-McClure, Abass Alavi
Journal of Nuclear Medicine May 2021, 62 (supplement 1) 1091;

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Evaluating the role of partial-volume correction in predicting survival in head and neck cancer
Mahdi Zirakchian Zadeh, Shadi Asadollahi, Fatemeh Kaghazchi, Siavash Mehdizadeh Seraj, William Raynor, Thomas Werner, Mona-Elisabeth Revheim, Jonathon Korostoff, Samuel Swisher-McClure, Abass Alavi
Journal of Nuclear Medicine May 2021, 62 (supplement 1) 1091;
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