Article Figures & Data
Figures
- FIGURE 1.
Chemical structure of 64/67Cu-CuSarbisPSMA.
- FIGURE 2.
(Left) Inhibition of LNCaP tumor growth after treatment with either 67Cu-CuSarbisPSMA or 177Lu-LuPSMA I&T, expressed as mean tumor volume (±SEM) (n = 5). (Right) Kaplan–Meier curve of percentage survival data; endpoint represents day on which tumor size was at least 1,200 mm3 or censoring occurred (day 82).
- FIGURE 3.
(A) Antitumor efficacy of 67Cu-CuSarbisPSMA against LNCaP tumor xenografts, expressed as average tumor size (±SEM) (n = 8). (B) Kaplan–Meier curve of percentage survival data; endpoint represents day on which tumor size was at least 1,200 mm3 or censoring occurred (day 85).
Tables
- TABLE 1
Percentage Growth Inhibition of LNCaP Tumors Treated with 67Cu-CuSarbisPSMA and 177Lu-LuPSMA I&T as Compared with Vehicle Control
Group Growth inhibition (%) P 67Cu-CuSarbisPSMA (5 MBq) 58 0.017 177Lu-LuPSMA I&T (5 MBq) 65 0.007 67Cu-CuSarbisPSMA (30 MBq) 109 <0.0001 177Lu-LuPSMA I&T (30 MBq) 107 <0.0001 Analysis was performed on day 17. P values were calculated relative to vehicle control.
- TABLE 2
Percentage Growth Inhibition of LNCaP Tumors Treated with 67Cu-CuSarbisPSMA as Compared with Vehicle Control
Group Growth inhibition (%) P 7.5 MBq 67Cu-CuSarbisPSMA 100 <0.001 15 MBq 67Cu-CuSarbisPSMA 112 <0.001 30 MBq 67Cu-CuSarbisPSMA 119 <0.001 Analysis was performed on day 13. P values were calculated relative to vehicle control.
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