First Clinical Results for PSMA-Targeted α-Therapy Using 225Ac-PSMA-I&amp;T in Advanced-mCRPC Patients

Mathias Johannes Zacherl; Franz Josef Gildehaus; Lena Mittlmeier; Guido Böning; Astrid Gosewisch; Vera Wenter; Marcus Unterrainer; Nina Schmidt-Hegemann; Claus Belka; Alexander Kretschmer; Jozefina Casuscelli; Christian G. Stief; Marcus Unterrainer; Peter Bartenstein; Andrei Todica; Harun Ilhan

doi:10.2967/jnumed.120.251017

Research ArticleClinical Investigation

First Clinical Results for PSMA-Targeted α-Therapy Using ²²⁵Ac-PSMA-I&T in Advanced-mCRPC Patients

Mathias Johannes Zacherl, Franz Josef Gildehaus, Lena Mittlmeier, Guido Böning, Astrid Gosewisch, Vera Wenter, Marcus Unterrainer, Nina Schmidt-Hegemann, Claus Belka, Alexander Kretschmer, Jozefina Casuscelli, Christian G. Stief, Marcus Unterrainer, Peter Bartenstein, Andrei Todica and Harun Ilhan

Journal of Nuclear Medicine May 2021, 62 (5) 669-674; DOI: https://doi.org/10.2967/jnumed.120.251017

Mathias Johannes Zacherl

1Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany

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Franz Josef Gildehaus

1Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany

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Lena Mittlmeier

1Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany

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Guido Böning

1Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany

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Astrid Gosewisch

1Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany

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Vera Wenter

1Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany

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Marcus Unterrainer

1Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany

2Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany

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Nina Schmidt-Hegemann

2Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany

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Claus Belka

2Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany

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Alexander Kretschmer

3Department of Urology, University Hospital, LMU Munich, Munich, Germany; and

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Jozefina Casuscelli

3Department of Urology, University Hospital, LMU Munich, Munich, Germany; and

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Christian G. Stief

3Department of Urology, University Hospital, LMU Munich, Munich, Germany; and

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Marcus Unterrainer

1Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany

4Department of Radiology, University Hospital, LMU Munich, Munich, Germany

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Peter Bartenstein

1Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany

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Andrei Todica

1Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany

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Harun Ilhan

1Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany

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First Clinical Results for PSMA-Targeted α-Therapy Using ²²⁵Ac-PSMA-I&T in Advanced-mCRPC Patients

Journal of Nuclear Medicine May 2021, 62 (5) 669-674; DOI: 10.2967/jnumed.120.251017

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First Clinical Results for PSMA-Targeted α-Therapy Using ²²⁵Ac-PSMA-I&T in Advanced-mCRPC Patients

Journal of Nuclear Medicine May 2021, 62 (5) 669-674; DOI: 10.2967/jnumed.120.251017

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Keywords

metastatic castration-resistant prostate cancer
radioligand therapy
targeted α-therapy
225Ac and 177Lu
PSMA

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