Journal of Nuclear Medicine: 62 (5)

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May 10, 2021; Volume 62,Issue 5

This Month in JNM

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This Month in JNM
Journal of Nuclear Medicine May 10, 2021, 62 (5) 10A;

Discussions with Leaders

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Challenges and Promise for Nuclear Medicine in Africa
Journal of Nuclear Medicine May 10, 2021, 62 (5) 593-595; DOI: https://doi.org/10.2967/jnumed.121.262179

The State of the Art

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Current and Emerging Clinical Applications of PSMA PET Diagnostic Imaging for Prostate Cancer
Andrea Farolfi, Letizia Calderoni, Francesco Mattana, Riccardo Mei, Sivi Telo, Stefano Fanti and Paolo Castellucci

Journal of Nuclear Medicine May 10, 2021, 62 (5) 596-604; DOI: https://doi.org/10.2967/jnumed.120.257238

Continuing Education

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Statistical Considerations in the Evaluation of Continuous Biomarkers
Mei-Yin C. Polley and James J. Dignam

Journal of Nuclear Medicine May 10, 2021, 62 (5) 605-611; DOI: https://doi.org/10.2967/jnumed.120.251520

Hot Topics

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Relationship Between Tau and Cognition in the Evolution of Alzheimer’s Disease: New Insights from Tau PET
Jeremy A. Tanner and Gil D. Rabinovici

Journal of Nuclear Medicine May 10, 2021, 62 (5) 612-613; DOI: https://doi.org/10.2967/jnumed.120.257824

Focus on Molecular Imaging

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What Is T+? A Gordian Knot of Tracers, Thresholds, and Topographies
Victor L. Villemagne, Brian J. Lopresti, Vincent Doré, Dana Tudorascu, Milos D. Ikonomovic, Samantha Burnham, Davneet Minhas, Tharick A. Pascoal, N. Scott Mason, Beth Snitz, Howard Aizenstein, Chester A. Mathis, Oscar Lopez, Christopher C. Rowe, William E. Klunk and Ann D. Cohen

Journal of Nuclear Medicine May 10, 2021, 62 (5) 614-619; DOI: https://doi.org/10.2967/jnumed.120.245423

Oncology

Clinical
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  Sentinel Lymph Node Biopsy in Breast Cancer with ^99mTc-Tilmanocept: A Multicenter Study on Real-Life Use of a Novel Tracer
  Sergi Vidal-Sicart, María Eugenia Rioja, Andrea Prieto, Elena Goñi, Isabel Gómez, María Dolores Albala, Luis Lumbreras, Luisa Fernanda León, José Ramón Gómez and Francisco Campos
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 620-627; DOI: https://doi.org/10.2967/jnumed.120.252064
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  ¹⁸F-FLT PET/CT Adds Value to ¹⁸F-FDG PET/CT for Diagnosing Relapse After Definitive Radiotherapy in Patients with Lung Cancer: Results of a Prospective Clinical Trial
  Tine Nøhr Christensen, Seppo W. Langer, Gitte Persson, Klaus Richter Larsen, Annika Loft, Annemarie Gjelstrup Amtoft, Anne Kiil Berthelsen, Helle Hjorth Johannesen, Sune Høgild Keller, Andreas Kjaer and Barbara Malene Fischer
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 628-635; DOI: https://doi.org/10.2967/jnumed.120.247742
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  Prognostic Value of 16α-¹⁸F-Fluoro-17β-Estradiol PET as a Predictor of Disease Outcome in Endometrial Cancer: A Prospective Study
  Shizuka Yamada, Hideaki Tsuyoshi, Makoto Yamamoto, Tetsuya Tsujikawa, Yasushi Kiyono, Hidehiko Okazawa and Yoshio Yoshida
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 636-642; DOI: https://doi.org/10.2967/jnumed.120.244319
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  Clinical Utility of ¹⁸F-FDG PET/CT for Staging and Treatment Planning in Urachal Adenocarcinoma
  Jeeban P. Das, Hebert A. Vargas, Soleen Ghafoor, Alvin C. Goh and Gary A. Ulaner
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 643-647; DOI: https://doi.org/10.2967/jnumed.120.251561
Translational
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  Photoacoustic Molecular Imaging for the Identification of Lymph Node Metastasis in Head and Neck Cancer Using an Anti-EGFR Antibody–Dye Conjugate
  Naoki Nishio, Nynke S. van den Berg, Brock A. Martin, Stan van Keulen, Shayan Fakurnejad, Eben L. Rosenthal and Katheryne E. Wilson
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 648-655; DOI: https://doi.org/10.2967/jnumed.120.245241
Basic
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  ⁸⁹Zr-Labeled Anti-PD-L1 Antibody PET Monitors Gemcitabine Therapy-Induced Modulation of Tumor PD-L1 Expression
  Kyung-Ho Jung, Jin Won Park, Jin Hee Lee, Seung Hwan Moon, Young Seok Cho and Kyung-Han Lee
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 656-664; DOI: https://doi.org/10.2967/jnumed.120.250720
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  Repurposing ¹¹C-PS13 for PET Imaging of Cyclooxygenase-1 in Ovarian Cancer Xenograft Mouse Models
  Amanda J. Boyle, Junchao Tong, Sami S. Zoghbi, Victor W. Pike, Robert B. Innis and Neil Vasdev
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 665-668; DOI: https://doi.org/10.2967/jnumed.120.249367

Theranostics

Clinical
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  First Clinical Results for PSMA-Targeted α-Therapy Using ²²⁵Ac-PSMA-I&T in Advanced-mCRPC Patients
  Mathias Johannes Zacherl, Franz Josef Gildehaus, Lena Mittlmeier, Guido Böning, Astrid Gosewisch, Vera Wenter, Marcus Unterrainer, Nina Schmidt-Hegemann, Claus Belka, Alexander Kretschmer, Jozefina Casuscelli, Christian G. Stief, Marcus Unterrainer, Peter Bartenstein, Andrei Todica and Harun Ilhan
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 669-674; DOI: https://doi.org/10.2967/jnumed.120.251017
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  Identification of PCWG3 Target Populations Is More Accurate and Reproducible with PSMA PET Than with Conventional Imaging: A Multicenter Retrospective Study
  Andrea Farolfi, Nader Hirmas, Andrei Gafita, Manuel Weber, Francesco Barbato, Axel Wetter, Riccardo Mei, Davide Pianori, Boris Hadaschik, Ken Herrmann, Paolo Castellucci, Stefano Fanti, Matthias Eiber and Wolfgang P. Fendler
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 675-678; DOI: https://doi.org/10.2967/jnumed.120.246603
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  Safety, Biodistribution, and Radiation Dosimetry of ¹⁸F-rhPSMA-7.3 in Healthy Adult Volunteers
  Tuula Tolvanen, Kari Kalliokoski, Simona Malaspina, Anna Kuisma, Salla Lahdenpohja, Ernst J. Postema, Matthew P. Miller and Mika Scheinin
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 679-684; DOI: https://doi.org/10.2967/jnumed.120.252114
- Open Access
  Effects of Repeated ¹³¹I-Meta-Iodobenzylguanidine Radiotherapy on Tumor Size and Tumor Metabolic Activity in Patients with Metastatic Neuroendocrine Tumors
  Keiichiro Yoshinaga, Takashige Abe, Shozo Okamoto, Yuko Uchiyama, Osamu Manabe, Yoichi M. Ito, Naomi Tamura, Natsue Ito, Naho Yoshioka, Komei Washino, Nobuo Shinohara, Nagara Tamaki and Tohru Shiga
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 685-694; DOI: https://doi.org/10.2967/jnumed.120.250803
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  Disparities in PET Imaging for Prostate Cancer at a Tertiary Academic Medical Center
  Matthew D. Bucknor, Daphne Y. Lichtensztajn, Tracy K. Lin, Hala T. Borno, Scarlett L. Gomez and Thomas A. Hope
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 695-699; DOI: https://doi.org/10.2967/jnumed.120.251751

AI/Advanced Image Analysis

Clinical
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  Repeatability of Radiomic Features of Brown Adipose Tissue
  Aria Nazeri, John P. Crandall, Tyler J. Fraum and Richard L. Wahl
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 700-706; DOI: https://doi.org/10.2967/jnumed.120.248674
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  Repeatability of ¹⁸F-FDG PET Radiomic Features in Cervical Cancer
  John P. Crandall, Tyler J. Fraum, MinYoung Lee, Linda Jiang, Perry Grigsby and Richard L. Wahl
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 707-715; DOI: https://doi.org/10.2967/jnumed.120.247999

Cardiovascular

Clinical
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  Absolute Quantitation of Cardiac ^99mTc-Pyrophosphate Using Cadmium-Zinc-Telluride–Based SPECT/CT
  Sharmila Dorbala, Mi-Ae Park, Sarah Cuddy, Vasvi Singh, Kyle Sullivan, Sirwoo Kim, Rodney H. Falk, Viviany R. Taqueti, Hicham Skali, Ron Blankstein, Camden Bay, Marie F. Kijewski and Marcelo F. Di Carli
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 716-722; DOI: https://doi.org/10.2967/jnumed.120.247312

Molecular Imaging

Basic
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  The Synthesis and Structural Requirements for Measuring Glucocorticoid Receptor Expression In Vivo with (±)-¹¹C-YJH08 PET
  Yangjie Huang, Ning Zhao, Yung-hua Wang, Charles Truillet, Junnian Wei, Matthew F.L. Parker, Joseph E. Blecha, Christopher R. Drake, Henry F. VanBrocklin, Diego Garrido-Ruiz, Matthew P. Jacobson, Rahul Aggarwal, Spencer C. Behr, Robert R. Flavell, David M. Wilson, Youngho Seo and Michael J. Evans
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 723-731; DOI: https://doi.org/10.2967/jnumed.120.249755

Physics and Instrumentation

Translational
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  Measurement of PET Quantitative Bias In Vivo
  Martin A. Lodge, Wojciech Lesniak, Michael A. Gorin, Kenneth J. Pienta, Steven P. Rowe and Martin G. Pomper
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 732-737; DOI: https://doi.org/10.2967/jnumed.120.251397
Basic
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  Total-Body Quantitative Parametric Imaging of Early Kinetics of ¹⁸F-FDG
  Tao Feng, Yizhang Zhao, Hongcheng Shi, Hongdi Li, Xuezhu Zhang, Guobao Wang, Patricia M. Price, Ramsey D. Badawi, Simon R. Cherry and Terry Jones
  
  Journal of Nuclear Medicine May 10, 2021, 62 (5) 738-744; DOI: https://doi.org/10.2967/jnumed.119.238113

Letters to the Editor

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From Mice to Humans: The Exocrine Pancreas Does Not Matter in Human GLP-1 Receptor Imaging
Martin Gotthardt, Lieke Joosten, Theodorus J.P. Jansen, Maarten Brom, Marti Boss and Stefanie M.A. Willekens

Journal of Nuclear Medicine May 10, 2021, 62 (5) 745; DOI: https://doi.org/10.2967/jnumed.120.259184
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Reply: From Mice to Humans: The Exocrine Pancreas Does Not Matter in Human GLP-1 Receptor Imaging
Greg M. Thurber

Journal of Nuclear Medicine May 10, 2021, 62 (5) 745-747; DOI: https://doi.org/10.2967/jnumed.121.262029
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Disparities in PET Imaging of Prostate Cancer at a Tertiary Academic Medical Center
Andrei Iagaru and Benjamin Franc

Journal of Nuclear Medicine May 10, 2021, 62 (5) 747-748; DOI: https://doi.org/10.2967/jnumed.120.258160
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Reply: Disparities in PET Imaging of Prostate Cancer at a Tertiary Academic Medical Center
Matthew D. Bucknor and Thomas A. Hope

Journal of Nuclear Medicine May 10, 2021, 62 (5) 748; DOI: https://doi.org/10.2967/jnumed.121.262332

SNMMI Newsline

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SNMMI Newsline
Journal of Nuclear Medicine May 10, 2021, 62 (5) 11N-22N;
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Current Landscape of Radiopharmaceutical Therapies: SNMMI Therapy Task Force Survey
Richard L. Wahl, Sukhjeet Ahuja and Bonnie Clarke

Journal of Nuclear Medicine May 10, 2021, 62 (5) 11N-16N;
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SNMMI Leadership Update: A Year of Progress Amid a Pandemic
Alan B. Packard

Journal of Nuclear Medicine May 10, 2021, 62 (5) 17N-22N;
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¹⁸F-FDG PET National Coverage Determination for Infection/Inflammation Retired
Theodore A. Henderson, Simon DeBruin and Philippe Briandet

Journal of Nuclear Medicine May 10, 2021, 62 (5) 18N-22N;

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