Abstract
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Objectives: To explore the relationship of F-18-FDG standardized uptake value (SUV)-derived parameters and mutation subtypes (deletions in exon 19 and a mutation in exon 21) in lung adenocarcinomas parameters with mutant epidermal growth factor receptors (EGFR) gene.
Methods: Data of 64 lung adenocarcinoma patients who underwent F-18-FDG PET/CT scans and EGFR gene mutation test were collected. The relationships of subtype mutation of EGFR gene with four parameters (maximum standardized uptake value, SUVmax), average of standardized uptake value (SUVmean), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of primary lesion based on F-18-FDG PET/CT and clinical characteristics were evaluated with univariate and multivariate Logistic regression, respectively.
Results: The mutant ratio of exon 19 and exon 21 was 23:41. When the parameters were continuous variables, univariate logistic regression showed exon 21 mutations were found more frequently in the EGFR positive patients with shorter maximum diameter of primary lesion (OR=0.942, 95%CI[0.890.0998]) and low level of MTV of primary lesion (pMTV), (OR=0.957,95%CI [0.923,0.991]). As dichotomous variables, in univariate regression shorter maximum diameter of primary lesion (<26.5mm:OR=3.759,95%CI[1.284,11.005]), high level SUVmax (≥4.35: OR=4.267, 95%CI[1.088,16.726]), low level pMTV (<11.2cm2: OR=7.000, 95%CI[1.798, 27.253]) would be significantly related to mutant exon 21 mutation.
Conclusions: The primary-lesion SUV-derived parameters from F-18-FDG PET/CT of lung adenocarcinoma patients with EGFR-gene mutation associate with mutant subtypes (exon 19 and 21 mutation) to some extent, nut this correlation might be limited. Key Words: Epidermal growth factor receptors (EGFR); Maximum standardized uptake value (SUVmax); Metabolic tumor volume (MTV); Total lesion glycolysis (TLG)