Abstract
1593
Introduction: Ischemic heart disease is the leading cause of cardiac mortality in patients with diabetes. An understanding of each patient’s coronary physiology and anatomic complexity is required to determine whether treating with medical therapy, coronary artery bypass grafting, or percutaneous coronary intervention will result in the best outcome. Myocardial flow reserve (MFR) obtained through non-invasive positron emission tomography (PET) and fractional flow reserve (FFR) obtained through invasive angiography are measurements used to make clinical decisions about revascularization. Our objective was to investigate the association between the MFR and FFR measurements in patients with diabetes. Methods: We conducted a retrospective chart review of 174 patients who underwent MFR and FFR measurements between 2012-2018. Data collected included patient demographics, cardiovascular risk factors and outcomes at 1 and 3 years were collected. Results: Of 174 patients, 68 had diabetes (DM+) and 106 did not (DM-). The average MFR for DM+ patients of 2.08 was significantly lower than the average MFR for DM- of 2.41 (p=0.0143), while there was no difference between the average FFR for DM+ of 0.80 and for DM- of 0.82 (p=0.1908). The nature of the relationship between the FFR and MFR differed in a statistically significant manner for patients with diabetes compared to those without (p=0.0233). Conclusions: Our study found that while FFR values did not seem to differ in patients depending on diabetes status, MFR measurements did. This provides further evidence to suggest that DM+ are more likely to have more diffuse, multi-vessel disease compared to DM-. In the future, we aim to explore whether FFR and MFR values are more likely to be discordant in DM+ compared to DM-, which will aid in the development of more robust treatment guidelines for patients with diabetes.