Abstract
1520
Objectives: Osteopetrosis is a rare clinical genetic bone disease with abnormal bone density of inherited bone dysplasias. Methods: Here we reported a 40 years old adult female with osteopetrosis scanned by CT, MRI and 99mTc-MDP SPECT whole body bone scanning. Results: The patient suffered multiple lymphadenopathy in bilateral neck, axilla and groin for one month and low fever for several days. The left cervical lymph node aspiration biopsy showed chronic lymphadenitis. CT images showed high density located at multiple thoracic vertebrae and sternum. MRI images showed large flank low-signal shadows in multiple thoracic vertebrae. 99mTc-MDP SPECT bone images showed some local increased radioactive uptakes at the sternum, bead-like radioactive clustered symmetrically at the bilateral costal vertebra joints and the junctions of the ribs and rib cartilages (the rib beads) on both sides, and symmetrically increased abnormal radioactive distribution at the bilateral sternoclavicular joint, humeral head, upper middle humerus, sacroiliac joint, pubic symphysis and lower middle femur. Radioactive uptakes symmetrically increased at the bilateral joints of ilium and ischium. The radiation distribution of the upper and lower edges of the vertebral body of the lumbar spine and the lower thoracic spine was increased and the center was sparse.
Conclusions: The characteristics of the 3 different imaging models concluded to the diagnosis of osteopetrosis and the 99mTc-MDP bone scanning is useful to the diagnosis of osteopetrosis.