Abstract
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Objectives: To investigate the value of 18F-FDG PET/CT in the diagnosis of renal cell carcinoma with rhabdoid differentiation (RCC-R) and differential diagnosis of clear cell renal cell carcinoma (ccRCC). Materials and Methods: Among patients with renal tumors confirmed by pathology from October 2010 to December 2019, six patients with RCC-R who underwent PET/CT examinations before treatment were studied. Eighty-two Patients with pathologically confirmed ccRCC who underwent PET/CT before surgery were selected as control group. The PET/CT features of two groups were retrospectively reviewed.
Results: Overall, there was no significant difference in diameter between the RCC-R and ccRCC groups (8.5 ± 3.0 vs 6.2 ± 3.4, Z = -1.865, P = 0.062). Metastasis was more common in RCC-R group than ccRCC group (5/1 vs 15/67, χ2 = 10.018, P = 0.002). SUVmax,SUVmean,SUVpeak of RCC-R group were significantly higher than ccRCC group (20.1 ± 14.2 vs 4.3 ± 3.3, Z = -3.784, P < 0.0001; 10.5 ± 5.9 vs 2.6 ± 1.7, Z = -3.788, P < 0.0001; 12.4 ± 7.4 vs 3.1 ± 2.2, Z = -3.729, P < 0.0001;), and the cut-off values of 7.7, 4.2 and 5.0 were helpful for discrimination.
Conclusions: Intense FDG uptake with higher SUVmax, SUVmean,SUVpeak are more commonly associated with RCC-R than ccRCC, and the cut-off values of 7.7, 4.2, 5.0, respectively, may be helpful to indicate RCC-R. Keywords: Renal cell carcinoma; rhabdoid; clear cell; X-ray, computed tomography; Positron-emission tomography