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Research ArticleOncology

First-in-Humans Imaging with 89Zr-Df-IAB22M2C Anti-CD8 Minibody in Patients with Solid Malignancies: Preliminary Pharmacokinetics, Biodistribution, and Lesion Targeting

Neeta Pandit-Taskar, Michael A. Postow, Matthew D. Hellmann, James J. Harding, Christopher A. Barker, Joseph A. O’Donoghue, Martha Ziolkowska, Shutian Ruan, Serge K. Lyashchenko, Frank Tsai, Michael Farwell, Tara C. Mitchell, Ron Korn, William Le, Jason S. Lewis, Wolfgang A. Weber, Deepak Behera, Ian Wilson, Michael Gordon, Anna M. Wu and Jedd D. Wolchok
Journal of Nuclear Medicine April 2020, 61 (4) 512-519; DOI: https://doi.org/10.2967/jnumed.119.229781
Neeta Pandit-Taskar
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York
2Department of Radiology, Weill Cornell Medical College, New York, New York
3Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York
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Michael A. Postow
4Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
5Department of Medicine, Weill Cornell Medical College, New York, New York
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Matthew D. Hellmann
3Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York
4Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
5Department of Medicine, Weill Cornell Medical College, New York, New York
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James J. Harding
4Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
5Department of Medicine, Weill Cornell Medical College, New York, New York
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Christopher A. Barker
6Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York
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Joseph A. O’Donoghue
7Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York
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Martha Ziolkowska
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York
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Shutian Ruan
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York
2Department of Radiology, Weill Cornell Medical College, New York, New York
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Serge K. Lyashchenko
8Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York
9Radiochemistry and Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, New York
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Frank Tsai
10Honor Health, Scottsdale, Arizona
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Michael Farwell
11University of Pennsylvania, Philadelphia, Pennsylvania
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Tara C. Mitchell
11University of Pennsylvania, Philadelphia, Pennsylvania
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Ron Korn
12Imaging Endpoints, Scottsdale, Arizona
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William Le
13ImaginAb, Inc., Inglewood, California; and
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Jason S. Lewis
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York
8Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York
9Radiochemistry and Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, New York
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Wolfgang A. Weber
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York
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Deepak Behera
13ImaginAb, Inc., Inglewood, California; and
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Ian Wilson
13ImaginAb, Inc., Inglewood, California; and
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Michael Gordon
10Honor Health, Scottsdale, Arizona
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Anna M. Wu
13ImaginAb, Inc., Inglewood, California; and
14Department of Molecular Imaging and Therapy, Beckman Research Institute of the City of Hope, Duarte, California
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Jedd D. Wolchok
5Department of Medicine, Weill Cornell Medical College, New York, New York
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Article Information

vol. 61 no. 4 512-519
DOI 
https://doi.org/10.2967/jnumed.119.229781
PubMed 
31586002

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication May 8, 2019
  • Accepted for publication August 21, 2019
  • Published online April 1, 2020.

Article Versions

  • previous version (October 4, 2019 - 13:09).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2020 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Neeta Pandit-Taskar1–3,
  2. Michael A. Postow4,5,
  3. Matthew D. Hellmann3–5,
  4. James J. Harding4,5,
  5. Christopher A. Barker6,
  6. Joseph A. O’Donoghue7,
  7. Martha Ziolkowska1,
  8. Shutian Ruan1,2,
  9. Serge K. Lyashchenko8,9,
  10. Frank Tsai10,
  11. Michael Farwell11,
  12. Tara C. Mitchell11,
  13. Ron Korn12,
  14. William Le13,
  15. Jason S. Lewis1,8,9,
  16. Wolfgang A. Weber1,
  17. Deepak Behera13,
  18. Ian Wilson13,
  19. Michael Gordon10,
  20. Anna M. Wu13,14 and
  21. Jedd D. Wolchok3–5
  1. 1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York
  2. 2Department of Radiology, Weill Cornell Medical College, New York, New York
  3. 3Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York
  4. 4Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
  5. 5Department of Medicine, Weill Cornell Medical College, New York, New York
  6. 6Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York
  7. 7Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York
  8. 8Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York
  9. 9Radiochemistry and Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, New York
  10. 10Honor Health, Scottsdale, Arizona
  11. 11University of Pennsylvania, Philadelphia, Pennsylvania
  12. 12Imaging Endpoints, Scottsdale, Arizona
  13. 13ImaginAb, Inc., Inglewood, California; and
  14. 14Department of Molecular Imaging and Therapy, Beckman Research Institute of the City of Hope, Duarte, California
  1. For correspondence or reprints contact: Neeta Pandit-Taskar, Memorial Sloan Kettering Cancer Center, 1275 York Ave., New York, NY 10065. E-mail: pandit-n{at}mskcc.org
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Journal of Nuclear Medicine: 61 (4)
Journal of Nuclear Medicine
Vol. 61, Issue 4
April 1, 2020
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First-in-Humans Imaging with 89Zr-Df-IAB22M2C Anti-CD8 Minibody in Patients with Solid Malignancies: Preliminary Pharmacokinetics, Biodistribution, and Lesion Targeting
Neeta Pandit-Taskar, Michael A. Postow, Matthew D. Hellmann, James J. Harding, Christopher A. Barker, Joseph A. O’Donoghue, Martha Ziolkowska, Shutian Ruan, Serge K. Lyashchenko, Frank Tsai, Michael Farwell, Tara C. Mitchell, Ron Korn, William Le, Jason S. Lewis, Wolfgang A. Weber, Deepak Behera, Ian Wilson, Michael Gordon, Anna M. Wu, Jedd D. Wolchok
Journal of Nuclear Medicine Apr 2020, 61 (4) 512-519; DOI: 10.2967/jnumed.119.229781

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First-in-Humans Imaging with 89Zr-Df-IAB22M2C Anti-CD8 Minibody in Patients with Solid Malignancies: Preliminary Pharmacokinetics, Biodistribution, and Lesion Targeting
Neeta Pandit-Taskar, Michael A. Postow, Matthew D. Hellmann, James J. Harding, Christopher A. Barker, Joseph A. O’Donoghue, Martha Ziolkowska, Shutian Ruan, Serge K. Lyashchenko, Frank Tsai, Michael Farwell, Tara C. Mitchell, Ron Korn, William Le, Jason S. Lewis, Wolfgang A. Weber, Deepak Behera, Ian Wilson, Michael Gordon, Anna M. Wu, Jedd D. Wolchok
Journal of Nuclear Medicine Apr 2020, 61 (4) 512-519; DOI: 10.2967/jnumed.119.229781
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Keywords

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