Synthesis of the PET Tracer 124I-Trametinib for MAPK/ERK Kinase Distribution and Resistance Monitoring

Edwin C. Pratt; Elizabeth Isaac; Evan P. Stater; Guangbin Yang; Ouathek Ouerfelli; Nagavarakishore Pillarsetty; Jan Grimm

doi:10.2967/jnumed.120.241901

Research ArticleRadiochemistry

Synthesis of the PET Tracer ¹²⁴I-Trametinib for MAPK/ERK Kinase Distribution and Resistance Monitoring

Edwin C. Pratt, Elizabeth Isaac, Evan P. Stater, Guangbin Yang, Ouathek Ouerfelli, Nagavarakishore Pillarsetty and Jan Grimm

Journal of Nuclear Medicine December 2020, 61 (12) 1845-1850; DOI: https://doi.org/10.2967/jnumed.120.241901

Edwin C. Pratt

1Department of Pharmacology, Weill Cornell Graduate School, New York, New York

2Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York

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Elizabeth Isaac

1Department of Pharmacology, Weill Cornell Graduate School, New York, New York

2Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York

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Evan P. Stater

1Department of Pharmacology, Weill Cornell Graduate School, New York, New York

2Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York

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Guangbin Yang

3Organic Synthesis Core, Memorial Sloan Kettering Cancer Center, New York, New York; and

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Ouathek Ouerfelli

3Organic Synthesis Core, Memorial Sloan Kettering Cancer Center, New York, New York; and

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Nagavarakishore Pillarsetty

2Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York

4Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

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Jan Grimm

1Department of Pharmacology, Weill Cornell Graduate School, New York, New York

2Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York

4Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

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Journal of Nuclear Medicine

Vol. 61, Issue 12

December 1, 2020

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Synthesis of the PET Tracer ¹²⁴I-Trametinib for MAPK/ERK Kinase Distribution and Resistance Monitoring

Edwin C. Pratt, Elizabeth Isaac, Evan P. Stater, Guangbin Yang, Ouathek Ouerfelli, Nagavarakishore Pillarsetty, Jan Grimm

Journal of Nuclear Medicine Dec 2020, 61 (12) 1845-1850; DOI: 10.2967/jnumed.120.241901

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Synthesis of the PET Tracer ¹²⁴I-Trametinib for MAPK/ERK Kinase Distribution and Resistance Monitoring

Edwin C. Pratt, Elizabeth Isaac, Evan P. Stater, Guangbin Yang, Ouathek Ouerfelli, Nagavarakishore Pillarsetty, Jan Grimm

Journal of Nuclear Medicine Dec 2020, 61 (12) 1845-1850; DOI: 10.2967/jnumed.120.241901

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trametinib
small-molecular inhibitor
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MEK
radiochemistry
oncology

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