Targeting Fibroblast Activation Protein: Radiosynthesis and Preclinical Evaluation of an 18F-Labeled FAP Inhibitor

Johannes Toms; Jürgen Kogler; Simone Maschauer; Christoph Daniel; Christian Schmidkonz; Torsten Kuwert; Olaf Prante

doi:10.2967/jnumed.120.242958

Research ArticleTheranostics

Targeting Fibroblast Activation Protein: Radiosynthesis and Preclinical Evaluation of an ¹⁸F-Labeled FAP Inhibitor

Johannes Toms, Jürgen Kogler, Simone Maschauer, Christoph Daniel, Christian Schmidkonz, Torsten Kuwert and Olaf Prante

Journal of Nuclear Medicine December 2020, 61 (12) 1806-1813; DOI: https://doi.org/10.2967/jnumed.120.242958

Johannes Toms

1Friedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Nuclear Medicine, Molecular Imaging and Radiochemistry, Translational Research Center, Erlangen, Germany

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Jürgen Kogler

1Friedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Nuclear Medicine, Molecular Imaging and Radiochemistry, Translational Research Center, Erlangen, Germany

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Simone Maschauer

1Friedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Nuclear Medicine, Molecular Imaging and Radiochemistry, Translational Research Center, Erlangen, Germany

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Christoph Daniel

2Friedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Nephropathology, Erlangen, Germany; and

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Christian Schmidkonz

3Friedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Nuclear Medicine, Erlangen, Germany

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Torsten Kuwert

3Friedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Nuclear Medicine, Erlangen, Germany

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Olaf Prante

1Friedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Nuclear Medicine, Molecular Imaging and Radiochemistry, Translational Research Center, Erlangen, Germany

3Friedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Nuclear Medicine, Erlangen, Germany

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Journal of Nuclear Medicine

Vol. 61, Issue 12

December 1, 2020

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Targeting Fibroblast Activation Protein: Radiosynthesis and Preclinical Evaluation of an ¹⁸F-Labeled FAP Inhibitor

Johannes Toms, Jürgen Kogler, Simone Maschauer, Christoph Daniel, Christian Schmidkonz, Torsten Kuwert, Olaf Prante

Journal of Nuclear Medicine Dec 2020, 61 (12) 1806-1813; DOI: 10.2967/jnumed.120.242958

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Targeting Fibroblast Activation Protein: Radiosynthesis and Preclinical Evaluation of an ¹⁸F-Labeled FAP Inhibitor

Johannes Toms, Jürgen Kogler, Simone Maschauer, Christoph Daniel, Christian Schmidkonz, Torsten Kuwert, Olaf Prante

Journal of Nuclear Medicine Dec 2020, 61 (12) 1806-1813; DOI: 10.2967/jnumed.120.242958

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Keywords

fibroblast activation protein
cancer-associated fibroblasts
18F
18F-fluoroglycosylation
PET

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