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Research ArticlePhysics and Instrumentation
Open Access

PennPET Explorer: Design and Preliminary Performance of a Whole-Body Imager

Joel S. Karp, Varsha Viswanath, Michael J. Geagan, Gerd Muehllehner, Austin R. Pantel, Michael J. Parma, Amy E. Perkins, Jeffrey P. Schmall, Matthew E. Werner and Margaret E. Daube-Witherspoon
Journal of Nuclear Medicine January 2020, 61 (1) 136-143; DOI: https://doi.org/10.2967/jnumed.119.229997
Joel S. Karp
1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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Varsha Viswanath
2Department of Biomedical Engineering, University of Pennsylvania, Philadelphia, Pennsylvania
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Michael J. Geagan
1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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Gerd Muehllehner
3KAGE Medical, Wayne, Pennsylvania; and
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Austin R. Pantel
1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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Michael J. Parma
1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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Amy E. Perkins
4Philips Healthcare, Highland Heights, Ohio
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Jeffrey P. Schmall
1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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Matthew E. Werner
1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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Margaret E. Daube-Witherspoon
1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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Abstract

We report on the development of the PennPET Explorer whole-body imager. Methods: The PennPET Explorer is a multiring system designed with a long axial field of view. The imager is scalable and comprises multiple 22.9-cm-long ring segments, each with 18 detector modules based on a commercial digital silicon photomultiplier. A prototype 3-segment imager has been completed and tested with an active 64-cm axial field of view. Results: The instrument design is described, and its physical performance measurements are presented. These include sensitivity of 55 kcps/MBq, spatial resolution of 4.0 mm, energy resolution of 12%, timing resolution of 256 ps, and a noise-equivalent count rate above 1,000 kcps beyond 30 kBq/mL. After an evaluation of lesion torso phantoms to characterize quantitative accuracy, human studies were performed on healthy volunteers. Conclusion: The physical performance measurements validated the system design and led to high-quality human studies.

  • PET
  • whole-body imager
  • NEMA performance

Footnotes

  • Published online Jun. 21, 2019.

  • © 2020 by the Society of Nuclear Medicine and Molecular Imaging.

Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

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Journal of Nuclear Medicine: 61 (1)
Journal of Nuclear Medicine
Vol. 61, Issue 1
January 1, 2020
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PennPET Explorer: Design and Preliminary Performance of a Whole-Body Imager
Joel S. Karp, Varsha Viswanath, Michael J. Geagan, Gerd Muehllehner, Austin R. Pantel, Michael J. Parma, Amy E. Perkins, Jeffrey P. Schmall, Matthew E. Werner, Margaret E. Daube-Witherspoon
Journal of Nuclear Medicine Jan 2020, 61 (1) 136-143; DOI: 10.2967/jnumed.119.229997

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PennPET Explorer: Design and Preliminary Performance of a Whole-Body Imager
Joel S. Karp, Varsha Viswanath, Michael J. Geagan, Gerd Muehllehner, Austin R. Pantel, Michael J. Parma, Amy E. Perkins, Jeffrey P. Schmall, Matthew E. Werner, Margaret E. Daube-Witherspoon
Journal of Nuclear Medicine Jan 2020, 61 (1) 136-143; DOI: 10.2967/jnumed.119.229997
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Keywords

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