Abstract
1247
Purpose: To explore the use of positron emission tomography (PET) parameters in differentiating different non-malignant cytological diagnoses of mediastinal lymphadenopathy.
Methods: A retrospective audit was conducted on all patients who underwent EBUS-TBNA in Westmead Hospital between 1/1/13 and 31/12/16. Patients with malignant or inconclusive diagnoses were excluded, and patients with PET scans were included for further analysis. PET parameters analysed include lymph node maximum standardised uptake value (SUVmax) and Hounsfield unit (HU), and statistical analysis was performed using Student’s t-test, comparing reactive lymphadenopathy, anthracosis, and granulomatous inflammation to benign lymphoid tissue.
Results: A total of 60 lymph nodes were included for analysis.
[asterisk] p<0.001
Conclusions: Granulomatous inflammation displayed higher SUVmax compared to benign lymphoid tissue. There was no significant difference in SUVmax or HU between reactive lymphadenopathy, anthracosis and benign lymphoid tissue. Clinical implications This study characterised PET parameters for different non-malignant diagnoses of mediastinal lymphadenopathy. Further studies with increased numbers, and studies to differentiate PET parameters between malignant and non-malignant disease will be valuable.