Abstract
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Aim: The aim of this study is to evaluate the correlation between metabolic tumor volume(MTV)40%,50%,60%,70% on 18 FDG PET/CT and clinicopathological features in patients with distant metastatic breast cancer (DMBC).
Results: 18 FDG PET/CT scans of 139(138 female,1male) DMBC patients (53.06±14.04 years-old) were analyzed between 2009-2018.A total 139 lesions were identified, and maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), were measured and correlated with patient survival by Cox regression analysis. Primary tumor mean SUV max was 13.97±9.21.84 (60.4%) patients have distant nodal metastasis and 104 (74.8%) have visseral organ metastasis;64 (46%) bone-bone marrow, 19(13.7%) multiple organ metastasis, 9(6.5%) liver, 7(5%) lung, 4(2.9%) dermal-subdermal, 1(0.7%) intramuscular metastasis. Mean follow-up time of 36,76±24,90 months(range:0.33-113.5 months).
Conclusions: There is a statistically significance between high MTV values(MTV 40%-70%), high axillary lymph node size(MTV 40%-70%), and distant nodal metastatis(MTV 50%-70%).(Table 1) Table 1. Comparison between mean MTV 40%-70% values in clinical and histopathological features of the patients.
[asterisk]= p<0.05 statistically significant. There is a statistically significance between high total lesion glycolysis (TLG) values, high primary tumor size (TLG 40%-70%), high Ki 67 rates (TLG 40%-70%),axillary involvement(TLG 40%),high axillary lymph node diameter(TLG 40%-70%),and distant nodal metastasis (TLG 40%-70%) (Table 2) Table 2. Comparison between mean TLG 40%-70% values in clinical and histopathological features of the patients.
Conclusions: In patients with DMBC, MTV appears to be a strong prognostic factor. If validated in prospective studies, MTV could be a valuable tool for risk stratification of DMBC patients to guide patient management.