In the article “Three-Dimensional Dosimetry for Radiation Safety Estimates from Intrathecal Administration,” by Hesterman et al. (J Nucl Med. 2017;58:1672–1678), the absorbed doses given in Table 3 and the in-text references to these values from Table 3 are incorrect. The correct values appear in italics in the paragraphs as well as the table below. Despite these errors, there is no impact to the methods, statistical analysis, or conclusions. The authors regret the error.
Absorbed Dose Per Unit Injected Activity for Regions of Interest (μGy/MBq)
In the abstract:
Simulation results were within 6% of OLINDA estimates for common organs. Absorbed dose estimates were highest (0.5–1.2 mGy/MBq) in the lumbar CSF space.
In the “Discussion: Clinical Data” section:
The lumbar CSF region experiences the highest exposure, with an absorbed dose per unit injected activity of approximately 1.2 ± 0.3 mGy/MBq for a 5-mL administered volume, with radiation dose decreasing along the spinal cord up to the brain. In the case of the 5-mL administration, the ratio of absorbed dose between lumbar and cervical CSF is approximately 6.0 and lumbar to brain tissue is about 32. A more uniform distribution of absorbed dose is observed with the 15-mL dose volume with lumbar–to–cervical and lumbar–to–brain tissue ratios of about 2.3 and 10.3, respectively. Additionally, the brain CSF, comprising largely the cisterns, and brain parenchyma doses are approximately 1.4 times higher in the 15-mL administered volume group than in the 5-mL group.
In the “Discussion: Biological Implications” section:
The current experimentally derived dosimetry after intrathecal administration indicates an absorbed dose per unit injected activity of up to 1.2 mGy/MBq in the lumbar spine (5-mL injection, n = 3 subjects). In this study, the administered activity of 99mTc was about 185 MBq, resulting in a total radiation dose of about 220 mGy (0.22 Gy).
In Table 3:
- © 2019 by the Society of Nuclear Medicine and Molecular Imaging.
