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Research ArticleTheranostics

Twelve-Year Follow-up After Peptide Receptor Radionuclide Therapy

Michael Gabriel, Bernhard Nilica, Bernhard Kaiser and Irene J. Virgolini
Journal of Nuclear Medicine April 2019, 60 (4) 524-529; DOI: https://doi.org/10.2967/jnumed.118.215376
Michael Gabriel
1Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria; and
2Institute of Nuclear Medicine and Endocrinology, Kepler University Hospital, Linz, Austria
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Bernhard Nilica
1Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria; and
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Bernhard Kaiser
2Institute of Nuclear Medicine and Endocrinology, Kepler University Hospital, Linz, Austria
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Irene J. Virgolini
1Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria; and
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Article Figures & Data

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  • FIGURE 1.
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    FIGURE 1.

    Graph showing number of deaths in various years. Of female patients, 3 died after 2008.

  • FIGURE 2.
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    FIGURE 2.

    Life-span curves showing clear sex difference, but with log-rank test giving P value of 0.195.

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    FIGURE 3.

    Kaplan–Meier curves clearly indicating that patients who showed cumulative disease control (complete response [CR] + partial response [PR] + minor response [MR] + stable disease [SD]) after initial PRRT regime had significantly better overall survival than did patients with progressive disease (PD) (P < 0.001, log rank).

  • FIGURE 4.
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    FIGURE 4.

    Graph showing that only 18% of patients initially treated with 90Y-therapy were alive after 12 y, whereas nearly 48% of patients in 177Lu group were alive.

Tables

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    TABLE 1

    Age of Deceased Patients at Date of Death or of Survivors on Final Date of Evaluation

    SexLife statusnMeanSDMinimumMaximum
    FemaleAlive855.46.24764
    Dead962.113.24178
    MaleAlive656.26.44762
    Dead2162.012.74084
    AllAlive1455.76.04764
    Dead3062.012.64084
    Both4460.011.34084
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    TABLE 2

    Analysis with Regard to Type of Primary Tumor

    Primary tumorAlive (n)Dead (n)Alive (%)Mean age at diagnosis (y)Median survival (mo)
    NET of pancreas41225.059.3 (SD, 11.9)42 (95% CI, 23–107)
    NET of small bowel6940.058.1 (SD, 10.6)125 (95% CI, 30–NA)
    NET unknown primary2250.059.8 (SD, 10.4)NA (95% CI, 75–NA)
    NET of lung1325.065.8 (SD, 5.9)49 (95% CI, 8–NA)
    NET of rectum1233.367.0 (SD, 17.0)115 (95% CI, 20–NA)
    Reticulum sarcoma, glomus tumor020.058.5 (SD, 20.5)51.0 (95% CI, 23–79)
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    TABLE 3

    Analysis According to Number of Affected Organ Systems

    No. of systemsAlive (n)Dead (n)Alive (%)Mean age at diagnosis (y)Median survival (mo)
    15741.760.8 (SD, 9.4)97 (95% CI, 23–NA)
    261528.660.0 (SD, 10.6)81 (95% CI, 41–127)
    3, 43827.359.3 (SD, 14.8)23 (95% CI, 18–NA)
    • NA = not applicable.

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    TABLE 4

    Analysis in Terms of Initial Response to Therapy and Median Overall Survival

    Response to therapyAlive (n)Dead (n)Alive (%)Mean age at diagnosis (y)Median survival (mo)
    Partial or complete response3730.065.6 (SD, 10.7)86 (95% CI, 23–NA)
    Stable disease or minor response111444.057.2 (SD, 10.2)125 (95% CI, 79–NA)
    Progressive disease090.061.6 (SD, 13.2)25 (95% CI, 16–46)
    • NA = not applicable.

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Journal of Nuclear Medicine: 60 (4)
Journal of Nuclear Medicine
Vol. 60, Issue 4
April 1, 2019
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Twelve-Year Follow-up After Peptide Receptor Radionuclide Therapy
Michael Gabriel, Bernhard Nilica, Bernhard Kaiser, Irene J. Virgolini
Journal of Nuclear Medicine Apr 2019, 60 (4) 524-529; DOI: 10.2967/jnumed.118.215376

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Twelve-Year Follow-up After Peptide Receptor Radionuclide Therapy
Michael Gabriel, Bernhard Nilica, Bernhard Kaiser, Irene J. Virgolini
Journal of Nuclear Medicine Apr 2019, 60 (4) 524-529; DOI: 10.2967/jnumed.118.215376
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Keywords

  • peptide receptor radionuclide therapy
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  • individualized therapy
  • long-term follow-up
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