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Research ArticleTheranostics
Open Access

68Ga-FAPI PET/CT: Biodistribution and Preliminary Dosimetry Estimate of 2 DOTA-Containing FAP-Targeting Agents in Patients with Various Cancers

Frederik L. Giesel, Clemens Kratochwil, Thomas Lindner, Manfred M. Marschalek, Anastasia Loktev, Wencke Lehnert, Jürgen Debus, Dirk Jäger, Paul Flechsig, Annette Altmann, Walter Mier and Uwe Haberkorn
Journal of Nuclear Medicine March 2019, 60 (3) 386-392; DOI: https://doi.org/10.2967/jnumed.118.215913
Frederik L. Giesel
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
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Clemens Kratochwil
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
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Thomas Lindner
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
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Manfred M. Marschalek
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
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Anastasia Loktev
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
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Wencke Lehnert
2ABX-CRO Advanced Pharmaceutical Services Forschungsgesellschaft m.b.H, Dresden, Germany
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Jürgen Debus
3Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany
4Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center, Heidelberg, Germany
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Dirk Jäger
5Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg, Germany
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Paul Flechsig
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
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Annette Altmann
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
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Walter Mier
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
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Uwe Haberkorn
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
6Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany; and
7Translational Lung Research Center Heidelberg, German Center for Lung Research, Heidelberg, Germany
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Article Information

vol. 60 no. 3 386-392
DOI 
https://doi.org/10.2967/jnumed.118.215913
PubMed 
30072500

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication June 7, 2018
  • Accepted for publication July 21, 2018
  • Published online March 1, 2019.

Article Versions

  • previous version (August 2, 2018 - 13:54).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2019 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

Author Information

  1. Frederik L. Giesel*,1,
  2. Clemens Kratochwil*,1,
  3. Thomas Lindner1,
  4. Manfred M. Marschalek1,
  5. Anastasia Loktev1,
  6. Wencke Lehnert2,
  7. Jürgen Debus3,4,
  8. Dirk Jäger5,
  9. Paul Flechsig1,
  10. Annette Altmann1,
  11. Walter Mier1 and
  12. Uwe Haberkorn1,6,7
  1. 1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
  2. 2ABX-CRO Advanced Pharmaceutical Services Forschungsgesellschaft m.b.H, Dresden, Germany
  3. 3Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany
  4. 4Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center, Heidelberg, Germany
  5. 5Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg, Germany
  6. 6Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany; and
  7. 7Translational Lung Research Center Heidelberg, German Center for Lung Research, Heidelberg, Germany
  1. For correspondence or reprints contact: Uwe Haberkorn, Department of Nuclear Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany. E-mail: uwe.haberkorn{at}med.uni-heidelberg.de
  1. ↵* Contributed equally to this work.

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Journal of Nuclear Medicine: 60 (3)
Journal of Nuclear Medicine
Vol. 60, Issue 3
March 1, 2019
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68Ga-FAPI PET/CT: Biodistribution and Preliminary Dosimetry Estimate of 2 DOTA-Containing FAP-Targeting Agents in Patients with Various Cancers
Frederik L. Giesel, Clemens Kratochwil, Thomas Lindner, Manfred M. Marschalek, Anastasia Loktev, Wencke Lehnert, Jürgen Debus, Dirk Jäger, Paul Flechsig, Annette Altmann, Walter Mier, Uwe Haberkorn
Journal of Nuclear Medicine Mar 2019, 60 (3) 386-392; DOI: 10.2967/jnumed.118.215913

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68Ga-FAPI PET/CT: Biodistribution and Preliminary Dosimetry Estimate of 2 DOTA-Containing FAP-Targeting Agents in Patients with Various Cancers
Frederik L. Giesel, Clemens Kratochwil, Thomas Lindner, Manfred M. Marschalek, Anastasia Loktev, Wencke Lehnert, Jürgen Debus, Dirk Jäger, Paul Flechsig, Annette Altmann, Walter Mier, Uwe Haberkorn
Journal of Nuclear Medicine Mar 2019, 60 (3) 386-392; DOI: 10.2967/jnumed.118.215913
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Keywords

  • Radiotracer Tissue Kinetics
  • cancer-associated fibroblasts
  • PET/CT
  • Biodistribution
  • dosimetry
  • fibroblast activation protein
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